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Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer
Sichuan University.
Sichuan University.
Sichuan University.
Sichuan University.
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2009 (English)In: Disease Markers, ISSN 0278-0240, Vol. 26, no 1, 27-34 p.Article in journal (Refereed) Published
Abstract [en]

We are just beginning to understand how microRNAs (miRNAs) are involved in tumor-related processes in humans. Applying real-time RT-PCR, we investigated the miR-31, miR-143 and miR-145 expression in 98 primary CRC specimens, along with the corresponding normal mucosa specimens, and analyze the relationship of their expression with clinicopathological features. Our results showed the miR-31 expression was up-regulated in CRC compared to normal mucosa (p = 0.001). Furthermore, miR-31 expression was positively related to advanced TNM stage (p = 0.026) and deeper invasion of tumors (p = 0.024). MiR-145 was down-regulated in both colon (p = 0.001) and rectal (p = 0.012) cancer. MiR-143 was only down-regulated in colon cancer (p = 0.023) but not in rectal cancer (p = 0.351). There was no relationship of miR-143 and miR-145 expression with other clinicopathological features (p > 0.05), except that the miR-145 expression was related to cancer site (p = 0.03). In conclusion, the miR-31 overexpression may be involved in the development and progression of CRC. The miR-143 and miR-145 may play a certain role in the development of colon and/or rectal cancers but not in progression of the disease.

Place, publisher, year, edition, pages
2009. Vol. 26, no 1, 27-34 p.
Keyword [en]
microRNA, colorectal cancer, tumor stage, real-time RT-PCR
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-17158DOI: 10.3233/DMA-2009-0601OAI: diva2:202148
Available from: 2009-03-07 Created: 2009-03-07 Last updated: 2013-03-19

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Sun, Xiao-Feng
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OncologyFaculty of Health SciencesDepartment of Oncology UHL
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