liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
TNFSF15 Polymorphisms Are Associated With Susceptibility to Inflammatory Bowel Disease in a New European Cohort
University of Paris.
University of Paris.
University of Paris.
University of Paris.
Show others and affiliations
2009 (English)In: AMERICAN JOURNAL OF GASTROENTEROLOGY, ISSN 0002-9270, Vol. 104, no 2, 384-391 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Inflammatory bowel disease (IBD), e. g., Crohns disease (CD) and ulcerative colitis (UC), is a complex genetic disorder. Tumor necrosis factor (ligand) superfamily, member 15 (TNFSF15) has been previously identified as a susceptibility gene for CD in Japanese and UK cohorts. This replication study was designed in order to confirm and further validate the role of TNFSF15 in IBD.

METHODS: A total of 666 IBD families (corresponding to 2,982 relatives) with European ancestry were genotyped for the rs6478108 and rs7869487 polymorphisms, which define the main TNFSF15 haplotypes previously associated with CD. An association between the main haplotypes and CD, UC and IBD was tested using the Genehunter TDT and Unphased statistics. Caspase recruitment domain 15 (CARD15)/TNFSF15 interaction and genotype/phenotype correlations were also studied.

RESULTS: The previously reported "high-risk" haplotype (A) was associated with IBD (P = 0.001) (OR = 1.25 (1.05-1.50)) and CD (P = 0.02) (OR = 1.31 (1.03-1.67)) whereas the "protective" (B) haplotype was significantly less transmitted to IBD and CD patients. No interaction between CARD15 and TNFSF15 was detected. We also failed to define a clinical subgroup of CD patients specifically associated with TNFSF15 haplotype A.

CONCLUSIONS: This study confirms that TNFSF15 or a closely linked gene is involved in the genetic predisposition to CD.

Place, publisher, year, edition, pages
2009. Vol. 104, no 2, 384-391 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-17171DOI: 10.1038/ajg.2008.36OAI: diva2:202162
Available from: 2009-03-07 Created: 2009-03-07 Last updated: 2009-08-21

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Almer, Sven
By organisation
Gastroenterology and Hepatology Faculty of Health SciencesDepartment of Endocrinology and Gastroenterology UHL
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 18 hits
ReferencesLink to record
Permanent link

Direct link