Effects of estradiol, progesterone, and norethisterone on regional concentrations of galanin in the rat brain
1999 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 20, no 6, 743-748 p.Article in journal (Refereed) Published
Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), frontal cortex (162%), occipital cortex (174%), hippocampus (170%), and median eminence (202%). A more profound difference with addition of progesterone or norethisterone was seen in the pituitary (529% and 467%, respectively). Sex steroids, particularly estradiol, modulate galanin concentrations not only in reproductive, but also in nonreproductive, brain regions.
Place, publisher, year, edition, pages
1999. Vol. 20, no 6, 743-748 p.
Galanin, Estradiol, Progesterone, Norethisterone, Hippocampus, Pituitary, Frontal cortex
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-13442DOI: 10.1016/S0196-9781(99)00057-1OAI: oai:DiVA.org:liu-13442DiVA: diva2:20734