Acupuncture Compared To Placebo Acupuncture in Radiotherapy-induced Nausea: a Randomized Controlled Study
2012 (English)In: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041, Vol. 23, no 5, 1353-1361 p.Article in journal (Refereed) Published
PURPOSE: To evaluate if verum (real) acupuncture is effective against nausea and vomiting during radiotherapy.
PATIENTS AND METHODS: We randomised blinded cancer patients to verum; penetrating “deqi” creating acupuncture (n=109) in the antiemetic acupuncture point PC6 (three cm above the wrist), or sham (n=106) with a non-penetrating sham needle at a non-acupuncture point six cm above the wrist 2-3 times/week. The patients daily during the radiotherapy period documented nausea and vomiting. Primary endpoint was number of patients with at least one episode of nausea during the whole radiotherapy period. RESULTS: Data was provided by 205 patients (95 %). In the verum acupuncture group, 70 % experienced nausea at least once during the radiotherapy period (p=0.12 compared to the sham group) (mean number of days of 10.1), 25 % vomited and 42 % used antiemetic drugs at least once. In the sham group 62 % experienced nausea (mean number of days 8.7), 28 % vomited and 37 % consumed antiemetic drugs. Ninety five percent in the verum and 96 % in the sham acupuncture group believed that the treatment had been effective against nausea. In both groups 67 % experienced positive effects on relaxation, mood, sleep or pain-reduction, and 89 % wished to receive the treatment again.
CONCLUSION: Acupuncture creating deqi is not more effective than sham in radiotherapy-induced nausea, but in this study nearly all patients in both groups experienced that the treatment was effective for nausea.
Place, publisher, year, edition, pages
2012. Vol. 23, no 5, 1353-1361 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-17235DOI: 10.1093/annonc/mdr402ISI: 000303336400040OAI: oai:DiVA.org:liu-17235DiVA: diva2:207683
funding agencies|Swedish Cancer Society| 04 0483 |Swedish Institute for Health Sciences (the Vardal institute)||County Council of Ostergotland| LIO-4998 2005-279-83 LIO-4762 LIO-7433 LIO-10456 LIO-20071 |University of Linkoping| C 40111 |Vardal Foundation-for Health Care Sciences and Allergy Research||Ostgota Cancer Fund||2009-03-122009-03-122013-09-12Bibliographically approved