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Long-term treatment results and the immunoglobulin G subclass distribution patterns of proteinase-3-antineutrophil cytoplasm antibody (ANCA) and myeloperoxidase-ANCA in ANCA-associated vasculitis
Linköping University, Department of Medical and Health Sciences, Nephrology. Linköping University, Faculty of Health Sciences. (Landstinget i Östergötland; Local Health Care Services in Central Östergötland; Department of Nephrology; Närsjukvården i centrala Östergötland; Njurmedicinska kliniken)
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
Sahlgrens University Hospital.
Sahlgrens University Hospital.
2009 (English)In: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 43, no 2, 160-170 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Small vessel vasculitis associated with antibodies to neutrophil cytoplasm antigens has been denominated antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV).

Material and methods: Ninety-eight patients with various forms of AAV with renal involvement were studied retrospectively with regard to treatment, side-effects and outcome. The immunoglobulin G (IgG) subclass distribution patterns in serum were determined in 51 patients with nephelometry and those of anti-proteinase-3 (PR3) and anti-myeloperoxidase (MPO) in 44 patients by enzyme-linked immunosorbent assay.

Results: Fifty-nine patients with a mean age of 63 years were given treatment with intermittent intravenous regimens of cyclophosphamide and continuous corticosteroids, whereas 39 patients with a mean age of 58 years were given continuous oral treatment. Malignancy, mainly due to skin tumours, was more common in AAV than in the general population. The total IgG subclass distribution pattern was asymmetric. The response to PR3 was of IgG1, IgG3 and IgG4 isotypes, while IgG1 and IgG3 predominated in the response to MPO.

Conclusion: The aberrant IgG subclass distribution pattern detected in the autoantibodies may be of importance in the pathogenesis of AAV.

Place, publisher, year, edition, pages
2009. Vol. 43, no 2, 160-170 p.
Keyword [en]
ANCA, associated vasculitis, cyclophosphamide, IgG subclasses, MPO-ANCA, plasmapheresis, PR3-ANCA, pulse treatment
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-17278DOI: 10.1080/00365590802519354OAI: oai:DiVA.org:liu-17278DiVA: diva2:208131
Available from: 2009-03-16 Created: 2009-03-16 Last updated: 2014-01-15Bibliographically approved

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Almroth, GabrielBerlin, Gösta

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NephrologyFaculty of Health SciencesDepartment of Clinical and Experimental MedicineDepartment of Clinical Immunology and Transfusion Medicine
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