Solid-phase synthesis of libraries generated from a 4-phenyl-2-carboxy-piperazine Scaffold
2001 (English)In: Journal of Combinatorial Chemistry, Vol. 3, no 6, 546-553 p.Article in journal (Refereed) Published
Strategies for finding novel structures of therapeutical interest are discussed. The rationale for the selection of the two scaffolds N4-(m-aminophenyl)-piperazine-2-carboxylic acid E and N4-(o-aminophenyl)-piperazine-2-carboxylic F is described. The synthesis of the appropriate precursors to scaffold E and F and their use in solid-phase chemistry are described. A 160-member library was produced combining these novel piperazine scaffolds with eight sulfonyl chlorides/acid chlorides and 10 amines. The compound library prepared was analyzed using LC-MS, showing the expected base peak in all wells at an average purity of 82%.
Place, publisher, year, edition, pages
2001. Vol. 3, no 6, 546-553 p.
IdentifiersURN: urn:nbn:se:liu:diva-13467DOI: 10.1021/cc010013oOAI: oai:DiVA.org:liu-13467DiVA: diva2:20821