Intravesical electrical stimulation: an experimental analysis of the mechanism of action
1992 (English)In: Journal of Urology, ISSN 0022-5347, Vol. 148, no 3, 920-924 p.Article in journal (Refereed) Published
The working mechanism of intravesical electrical stimulation (IVES) was evaluated in alpha-chloralose anaesthetized cats and rats. IVES involved a direct activation of bladder mechanoreceptor afferents of the A delta type and as a consequence a central reflex activation of the detrusor. The detrusor response was abolished by bilateral transection of the S1-S3 dorsal roots and by intravesical instillation of lidocaine. The optimal stimulation frequency was 20 Hz. The results offer a theoretical rationale for the use of IVES as treatment of weak detrusor contractility in man.
Place, publisher, year, edition, pages
1992. Vol. 148, no 3, 920-924 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-13504OAI: oai:DiVA.org:liu-13504DiVA: diva2:20875