Two Modes of Acupuncture as a Treatment for Hot Flushes in Men with Prostate Cancer—A Prospective Multicenter Study with Long-Term Follow-Up
2009 (English)In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 55, no 1, 156-163 p.Article in journal (Refereed) Published
Background: Hot flushes are common and distressing among men with castrational treatment for prostate cancer. Of the few treatments, most have side effects.
Objective: Assess changes in hot flushes of electrostimulated (EA) and traditional acupuncture (TA).
Design, Setting, and Participants: Thirty-one men with hot flushes due to prostate cancer treatment were recruited from three urological departments in Sweden, from 2001 to 2004.
Intervention: Thirty-one men were randomized to EA (4 electrostimulated needle points) or TA (12 needle points) weekly for 12 wk.
Measurements: Primary outcome: number of and distress from hot flushes in 24h and change in “hot flush score.” Secondary outcome: change in 24-h urine excretion of CGRP (calcitonin gene–related peptide).
Results and Limitations: Twenty-nine men completed the treatment. Hot flushes per 24h decreased significantly, from a median of 7.6 (interquartile range [IQR], 6.0–12.3) at baseline in the EA group to 4.1 (IQR, 2.0–6.5) (p=0.012) after 12 wk, and from 5.7 (IQR, 5.1–9.5) in the TA group to 3.4 (IQR1.8–6.3) (p=0.001). Distress by flushes decreased from 8.2 (IQR, 6.5–10.7) in the EA group to 3.3 (IQR, 0.3–8.1) (p=0.003), and from 7.6 (IQR, 4.7–8.3) to 3.4 (IQR, 2.0–5.6) (p=0.001) in the TA group after 12 wk, (78% and 73% reduction in “hot flush score,” respectively). The effect lasted up to 9 mo after treatment ended. CGRP did not change significantly. Few, minor side effects were reported.
Limitations: small number of patients; no placebo control, instead a small group controlled for 6 wk pretreatment.
Conclusions: EA and TA lowered number of and distress from hot flushes. The hot flush score decreased 78% and 73%, respectively, in line with or better than medical regimens for these symptoms. Acupuncture should be considered an alternative treatment for these symptoms, but further evaluation is needed, preferably with a non- or placebo-treated control group.
Place, publisher, year, edition, pages
2009. Vol. 55, no 1, 156-163 p.
Hot flushes, Prostate neoplasms, Acupuncture, Castration
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-12621DOI: 10.1016/j.eururo.2008.02.002OAI: oai:DiVA.org:liu-12621DiVA: diva2:2088
Jessica Frisk, Anna-Clara Spetz, Hans Hjertberg, Bill Petersson, Mats Hammar, Two Modes of Acupuncture as a Treatment for Hot Flushes in Men with Prostate Cancer—A Prospective Multicenter Study with Long-Term Follow-Up, 2008, European Urology.
Copyright: Elsevier B.V., http://www.elsevier.com/