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Prolonged enhancement of the micturition reflex in the cat by repetitive stimulation of bladder afferents
Linköping University, Department of Clinical and Experimental Medicine, Cellbiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Cellbiology. Linköping University, Faculty of Health Sciences.
1999 (English)In: The Journal of General Physiology, ISSN 0022-1295, Vol. 517, no 2, 599-605 p.Article in journal (Refereed) Published
Abstract [en]
  1. Prolonged modulation of the parasympathetic micturition reflex was studied in cats anaesthetized by -chloralose. Reflex discharges were recorded from a thin pelvic nerve filament to the bladder and evoked by stimulation of the remaining ipsilateral bladder pelvic nerves or urethral branches of the pudendal nerve.


  2. Stimulation of bladder or urethral afferents at A intensity evoked micturition reflexes with a latency of 90-120 ms. Such reflexes were much enhanced following repetitive conditioning stimulation of the same afferents at 20 Hz for 5 min.


  3. The reflex enhancement lasted more than 1 h after the conditioning stimulation. The effect was not prevented by a preceding complete transection of the sympathetic supply to the bladder. A prolonged suppression of the reflex was obtained after conditioning stimulation of afferents in the dorsal clitoris nerves.


  4. It is proposed that the prolonged modulations of the micturition reflex represent physiological adaptive processes, which preserve a flawless function of the bladder during life. The observations provide a theoretical explanation for the beneficial effect of electric nerve stimulation in patients with voiding disorders.
Place, publisher, year, edition, pages
1999. Vol. 517, no 2, 599-605 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-13509OAI: diva2:20880
Available from: 1999-02-25 Created: 1999-02-25 Last updated: 2009-02-16Bibliographically approved
In thesis
1. Prolonged Modulation of the Micturition Reflex by Electrical Stimulation
Open this publication in new window or tab >>Prolonged Modulation of the Micturition Reflex by Electrical Stimulation
1999 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Intravesical electrical stimulation (IVES) has been used in treatment of patients with urinary bladder dysfunctions for more than four decades. While some investigators have reported excellent results others have observed less convincing effects or outright failures. The discrepancies may reflect differences in patient selection or stimulation procedure. A better theoretical understanding of the IVES working mechanism might help to improve the success rate of the treatment. The aims of the present study were to provide such information.

Experiments were performed on adult female cats and rats under /alpha/-chloralose anesthesia. IVES was delivered by a catheter electrode in the bladder. At proper intensity and frequency, IVES evoked reflex detrusor contractions that were abolished by bilateral rhizotomy of sacral dorsal roots. Stimulation parameters and response characteristics revealed that bladder mechanoreceptor A/delta/ afferents were activated by the IVES, the same afferents that drive the normal micturition reflex.

Five minutes of continues IVES at 20 Hz induced a prolonged, significant decrease in the micturition threshold volume of anesthetized rats. Similarly, selective bladder A/delta/ afferent stimulation induced a long-lasting enhancement of micturition reflex discharges in cats. A comparable prolonged inhibitory effect on the micturition reflex was demonstrated after ano-genital afferent stimulation. Both modulatory effects occurred without changes in response sensitivity of stimulated afferents. The IVES induced modulation was prevented by transient exposure of the bladder to a local anesthetic and by systemic administration of a glutamate NMDA receptor antagonist.

In conclusion, IVES induces a prolonged modulation of the micturition reflex by an LTP like enhancement of excitatory synaptic transmission in the central micturition reflex pathway. The findings provide an experimental explanation for the neuronal mechanisms underlying the curative effect of IVES in patients with bladder evacuation problems.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 1999. 50 p.
Linköping University Medical Dissertations, ISSN 0345-0082 ; 582
Intravesical electrical stimulation, IVES, bladder evacuation problems, bladder, micturition reflex
National Category
Urology and Nephrology
urn:nbn:se:liu:diva-4989 (URN)91-7219-326-3 (ISBN)
Public defence
1999-02-12, Berzeliussalen, Hälsouniversitetet, Campus US, Linköpings universitet, Linköping, 13:00 (English)
On the day of the public defence the status of article V was: Accepted.Available from: 1999-02-25 Created: 1999-02-25 Last updated: 2012-01-24Bibliographically approved

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