Prolonged enhancement of the micturition reflex in the cat by repetitive stimulation of bladder afferents
1999 (English)In: The Journal of General Physiology, ISSN 0022-1295, Vol. 517, no 2, 599-605 p.Article in journal (Refereed) Published
- Prolonged modulation of the parasympathetic micturition reflex was studied in cats anaesthetized by -chloralose. Reflex discharges were recorded from a thin pelvic nerve filament to the bladder and evoked by stimulation of the remaining ipsilateral bladder pelvic nerves or urethral branches of the pudendal nerve.
- Stimulation of bladder or urethral afferents at A intensity evoked micturition reflexes with a latency of 90-120 ms. Such reflexes were much enhanced following repetitive conditioning stimulation of the same afferents at 20 Hz for 5 min.
- The reflex enhancement lasted more than 1 h after the conditioning stimulation. The effect was not prevented by a preceding complete transection of the sympathetic supply to the bladder. A prolonged suppression of the reflex was obtained after conditioning stimulation of afferents in the dorsal clitoris nerves.
- It is proposed that the prolonged modulations of the micturition reflex represent physiological adaptive processes, which preserve a flawless function of the bladder during life. The observations provide a theoretical explanation for the beneficial effect of electric nerve stimulation in patients with voiding disorders.
Place, publisher, year, edition, pages
1999. Vol. 517, no 2, 599-605 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-13509OAI: oai:DiVA.org:liu-13509DiVA: diva2:20880