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Taurine in plasma and CSF: a study in healthy male volunteers
Linköping University, Department of Clinical and Experimental Medicine, Psychiatry . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Uppsala University Hospital.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Linköping University, Department of Clinical and Experimental Medicine, Psychiatry . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
2009 (English)In: Amino Acids, ISSN 0939-4451, Vol. 36, no 3, 529-533 p.Article in journal (Refereed) Published
Abstract [en]

In order to explore the interrelationship between plasma and cerebrospinal fluid taurine concentrations, three consecutive 6-ml fractions of cerebrospinal fluid were drawn from 30 healthy male volunteers in the early morning after 8 h in the fasting condition. Repeated plasma samples were drawn over 24 h the day before lumbar puncture. Taurine in plasma and cerebrospinal fluid was determined by high performance liquid chromatography. The subjects were categorized as extensive or poor metabolizers with respect to the cytochrome P450 2D6 genotype. The taurine cerebrospinal fluid/plasma ratio at 8 a.m. was negatively influenced by the plasma taurine concentration at 4 p.m. the previous day. It was also negatively influenced by body mass index and positively by the intraspinal pressure. Three poor metabolizers of cytochrome P450 2D6 had higher plasma taurine areas under the curve than 27 extensive metabolizers. Hypothetically, cytochrome P450 2D6 influences the transport of taurine across the blood-brain barrier.

Place, publisher, year, edition, pages
2009. Vol. 36, no 3, 529-533 p.
Keyword [en]
Taurine, Cerebrospinal fluid, Plasma, Cytochrome P450 2D6, Genotype
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-17389DOI: 10.1007/s00726-008-0115-9OAI: oai:DiVA.org:liu-17389DiVA: diva2:208931
Available from: 2009-03-21 Created: 2009-03-21 Last updated: 2012-10-15
In thesis
1. Taurine and Glutathione in cerebrospinal fluid and plasma from patients with psychiatric disorders and healthy controls
Open this publication in new window or tab >>Taurine and Glutathione in cerebrospinal fluid and plasma from patients with psychiatric disorders and healthy controls
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A growing body of results indicate that immunological alterations and oxidative stress are of importance in various mental disorders. The inflammatory changes are possible to detect both in plasma and cerebrospinal fluid (CSF), and different psychiatric disorder exhibit similar changes indicating a common underlying mechanism. The antioxidants are of importance to regulate the redox balance and control the inflammatory processes but the causal relationship between psychiatric disorders and increased oxidative stress is however not fully clarified. Two important antioxidants; taurine and glutathione (GSH), have been suggested to have central nervous system (CNS)-protective properties. They have been found to fluctuate in several mental disorders including schizophrenia and depression but the clinical relevance need further studies.

The general aim of this thesis was to increase the understanding of taurine and the GSH in depression and schizophrenia, two major mental disorders, in comparison to healthy controls.

Correlations between glutathione and taurine levels in blood and CSF were analyzed in healthy male volunteers and we identified a complex pattern of associations showing that the CSF concentration was influenced by body mass index (BMI), age, intraspinal pressure, plasma concentrations the previous day and possible genetic factors. Electroconvulsive therapy (ECT) is used in the treatment of severely depressed patients. In blood collected before the first and after the third ECT, we found a significant decrease in plasma taurine in patients responding to the treatment, while total glutathione was unaltered. In a group of olanzapine treated patients with schizophrenia or schizoaffective disorders, we analysed taurine and glutathione in plasma and CSF and compared with healthy male and female volunteers. We observed increased plasma taurine levels in patients compared with controls, but no difference in CSF taurine and no alteration in glutathione.

This thesis indicates that taurine might play a role in mental disorders such as depression and schizophrenia. Increased knowledge about the complex regulation of taurine and glutathione might provide new insights into the impact of redox balance in the pathophysiology of psychiatric disorder and contribute to a future personalization of the treatment.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2012. 65 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1316
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-84609 (URN)978-91-7519-850-7 (ISBN)
Public defence
2012-11-09, Eken, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Opponent
Supervisors
Available from: 2012-10-15 Created: 2012-10-15 Last updated: 2017-08-30Bibliographically approved

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Samuelsson, MartinGupta, RameshNordin, Conny

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