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Inflammation and cortisol response in coronary artery disease
County Hospital Ryhov.
Linköping University, Department of Medicine and Health Sciences, Cardiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
2009 (English)In: ANNALS OF MEDICINE, ISSN 0785-3890, Vol. 41, no 3, 224-233 p.Article in journal (Refereed) Published
Abstract [en]

Atherosclerosis is characterized by chronic inflammation involving autoimmune components. The degree of inflammatory activity, as detectable both within the atherosclerotic plaque and in the circulation, is associated with plaque destabilization and atherothrombotic complications. Endogenous glucocorticoids are modulators of innate and acquired immune responses, and as such play a key role in the reciprocal interaction between neuroendocrine and immune systems. Abnormalities in hypothalamic-pituitary-adrenal axis (HPA) function have been described in several chronic inflammatory disorders, and evidence has emerged lately that HPA dysfunction may be implicated also in the pathogenesis of coronary artery disease. This review is an outline of knowledge gained so far by previous studies of glucocorticoids in coronary atherosclerosis and myocardial infarction. The results consistently point towards a dysregulated cortisol secretion that may involve a failure to contain inflammatory activity. A dysfunctional HPA axis and its possible implications for coronary artery disease progress, including the hypothetical link between stress and inflammation, are discussed.

Place, publisher, year, edition, pages
2009. Vol. 41, no 3, 224-233 p.
Keyword [en]
Coronary artery disease, cortisol, glucocorticoids, HPA axis, inflammation, stress
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-17630DOI: 10.1080/07853890802508934OAI: diva2:210926
Available from: 2009-04-07 Created: 2009-04-06 Last updated: 2009-08-19

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Jonasson, Lena
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Cardiology Faculty of Health SciencesDepartment of Cardiology
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ReferencesLink to record
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