liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study
Lund University Hospital, Sweden.
Lund University Hospital, Sweden.
Karolinska University Hospital, Huddinge, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2009 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 80, no 1, 41-45 p.Article in journal (Refereed) Published
Abstract [en]

Background and purpose

Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement.

Patients and methods

We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years.


There was no difference in migration of implants between the two groups.


With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.

Place, publisher, year, edition, pages
Informa Healthcare, 2009. Vol. 80, no 1, 41-45 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-17633DOI: 10.1080/17453670902804968PubMedID: 19297788OAI: diva2:210964
Available from: 2009-04-07 Created: 2009-04-06 Last updated: 2013-10-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Aspenberg, Per
By organisation
Orthopaedics and Sports MedicineFaculty of Health SciencesDepartment of Orthopaedics Linköping
In the same journal
Acta Orthopaedica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 60 hits
ReferencesLink to record
Permanent link

Direct link