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Muscle function in Juvenile Chronic Arthritis
Linköping University, Department of Clinical and Experimental Medicine, Clinical Neurophysiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of Neurophysiology UHL.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
1995 (English)In: Journal of Rheumatology, ISSN 0315-162X, Vol. 22, no 6, 1159-1165 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE. Muscle strength and thickness were studied in children with juvenile chronic arthritis (JCA) to evaluate their muscle function. METHODS. We studied voluntary isometric, isokinetic, and nonvoluntary isometric muscle strength, as well as muscle thickness, in 20 children with JCA. Thickness of the quadriceps muscle was measured by ultrasound. Results were compared with reference values for healthy children and a matched control group. RESULTS. Isometric muscle strength in knee extensors, elbow flexors, and wrist dorsiflexors was reduced in children with JCA. In muscles near an inflamed joint, the strength was 45-65% of expected value. In muscles without adjacent arthritis, the strength was slightly decreased (80-90% of expected value). Isometric and isokinetic strength in ankle dorsiflexors was reduced only in children with ankle arthritis. Nonvoluntary muscle strength in thumb adductors during electrical stimulation of the ulnar nerve was reduced in children with arthritis in the hand. Thickness of the quadriceps muscle was reduced both in children with and without knee arthritis (75 and 90% of expected). CONCLUSION. Children with JCA have reduced muscle strength and thickness, which is most pronounced in muscles near an inflamed joint.

Place, publisher, year, edition, pages
1995. Vol. 22, no 6, 1159-1165 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-13644OAI: oai:DiVA.org:liu-13644DiVA: diva2:21104
Available from: 2004-05-27 Created: 2004-05-27 Last updated: 2009-08-19
In thesis
1. Muscle function in Juvenile Idiopathic Arthritis: A two-year follow-up
Open this publication in new window or tab >>Muscle function in Juvenile Idiopathic Arthritis: A two-year follow-up
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This is a study of muscle function in Juvenile Idiopathic Arthritis (JIA). Rheumatoid arthritis (RA) is a disease that primarily affects the synovial membrane of joints. Muscle weakness, atrophy and pain occur in adult RA. This may be a consequence of joint pain, stiffness and immobility. Muscle inflammation and neuropathy occur as complications in adults. Muscle function in JIA has been much less studied.

The aim of the study was to examine whether muscle weakness and atrophy also occur in children with JIA.

This was a longitudinal study over a two-year period, where muscle strength and thickness were measured repeatedly in a group of 20 children and teenagers with JIA. Muscle strength was measured using different methods and in several muscle groups. Muscle biopsies were obtained and nerve conduction velocity studies performed.

The study concludes that, compared to healthy people, children and teenagers with JIA have as a group reduced muscle strength and muscle thickness. For most of these children and teenagers, muscle strength is only slightly lower than expected, but a few have marked muscle weakness. This is most apparent in patients with severe polyarthritis where the weakness seems to be widespread. Patients with isolated arthritis may also have greatly reduced strength and thickness of muscles near the inflamed joint.

There is a risk of decreasing strength in patients with polyarthritis and in muscles near an active arthritis.

Minor changes are common in muscle biopsies, and findings may indicate immunological activity in the muscles.

Atrophy of type II fibres, as in adult RA, was not found in JIA.

No patient had signs of neuropathy.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2004. 97 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 847
Keyword
arthritis, juvenile rheumatoid, physiopathology, muscle, skeletal, pathology, physiopathology, Muscular atrophy, etiology, physiopathology, arthritis, juvenile rheumatoid, complications
National Category
Clinical Science
Identifiers
urn:nbn:se:liu:diva-5195 (URN)91-7373-819-0 (ISBN)
Public defence
2004-05-07, Viktoriasalen, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Supervisors
Note
On the day of the public defence the status of article IV was: Submitted.Available from: 2004-05-27 Created: 2004-05-27 Last updated: 2012-01-25Bibliographically approved

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Lindehammar, HansBäckman, Eva

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