Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson´s disease - an rCBF scintigraphy study
2007 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, Vol. 116, no 6, 347-354 p.Article in journal (Refereed) Published
Objectives: The aim of the study was to visualize cortical function in Parkinson's patients with various degrees of cognitive impairment.
Materials and methods: Thirty-seven patients with Parkinson's disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using 99mTC-HMPAO-SPECT.
Results: Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment (n = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment (n = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia (n = 10).
Conclusions: The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction.
Place, publisher, year, edition, pages
2007. Vol. 116, no 6, 347-354 p.
Parkinson's disease, cognitive impairment, SPECT, blood flow, Alzheimer's disease
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-17715DOI: 10.1111/j.1600-0404.2007.00887.xOAI: oai:DiVA.org:liu-17715DiVA: diva2:211541