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Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson´s disease - an rCBF scintigraphy study
Sahlgrenska University Hospital.
Linköping University, Department of Medicine and Health Sciences, Radiation Physics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics.
Sahlgrenska University Hospital.
Sahlgrenska University Hospital.
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2007 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, Vol. 116, no 6, 347-354 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: The aim of the study was to visualize cortical function in Parkinson's patients with various degrees of cognitive impairment.

Materials and methods: Thirty-seven patients with Parkinson's disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using 99mTC-HMPAO-SPECT.

Results: Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment (n = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment (n = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia (n = 10).

Conclusions: The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction.

Place, publisher, year, edition, pages
2007. Vol. 116, no 6, 347-354 p.
Keyword [en]
Parkinson's disease, cognitive impairment, SPECT, blood flow, Alzheimer's disease
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-17715DOI: 10.1111/j.1600-0404.2007.00887.xOAI: diva2:211541
Available from: 2009-04-16 Created: 2009-04-16 Last updated: 2009-08-21

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Ekberg, StefanGranérus, Ann-KathrineGranerus, Göran
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Radiation Physics Faculty of Health SciencesDepartment of Radiation PhysicsGeriatric Department of Geriatric MedicineClinical Physiology Department of Clinical Physiology
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Acta Neurologica Scandinavica
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