Is it possible to predict treatment response to a proton pump inhibitor in functional dyspepsia?
2003 (English)In: Alimentary Pharmacology and Therapeutics, Vol. 18, no 1, 117-124 p.Article in journal (Refereed) Published
Background: The efficacy of proton pump inhibitors in functional dyspepsia is modest and the prognostic factors are almost unknown.
Methods: Data were pooled on patients (n = 826) with a diagnosis of functional dyspepsia from two placebo-controlled trials who were treated with omeprazole, 10 or 20 mg once daily, for 4 weeks. Self-administered questionnaires for the assessment of symptoms and health-related quality of life were completed before entry, and epigastric pain/discomfort was recorded on diary cards. Treatment success was defined as the complete absence of epigastric pain/discomfort on each of the last 3 days of week 4. Prognostic factors were identified by multiple logistic regression analysis.
Results: The most discriminating predictor of treatment success (P < 0.0001) was the number of days with epigastric pain/discomfort during the first week of treatment. Fewer days with symptoms during the first week led to higher response rates at 4 weeks. In addition, age > 40 years, bothersome heartburn, low scores for bloating, epigastric pain and diarrhoea, history of symptoms for < 3 months and low impairment of vitality at baseline were identified as positive predictors of outcome.
Conclusions: Early response to treatment with a proton pump inhibitor, during the first week, seems to predict the outcome after 4 weeks in patients with functional dyspepsia.
Place, publisher, year, edition, pages
2003. Vol. 18, no 1, 117-124 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-13688DOI: 10.1046/j.1365-2036.2003.01651.xOAI: oai:DiVA.org:liu-13688DiVA: diva2:21161