liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Population genomics of the inbred Scandinavian wolf
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
Uppsala University.
Show others and affiliations
2009 (English)In: MOLECULAR ECOLOGY, ISSN 0962-1083 , Vol. 18, no 7, 1341-1351 p.Article in journal (Refereed) Published
Abstract [en]

The Scandinavian wolf population represents one of the genetically most well-characterized examples of a severely bottlenecked natural population (with only two founders), and of how the addition of new genetic material (one immigrant) can at least temporarily provide a genetic rescue. However, inbreeding depression has been observed in this population and in the absence of additional immigrants, its long-term viability is questioned. To study the effects of inbreeding and selection on genomic diversity, we performed a genomic scan with approximately 250 microsatellite markers distributed across all autosomes and the X chromosome. We found linkage disequilibrium (LD) that extended up to distances of 50 Mb, exceeding that of most outbreeding species studied thus far. LD was particularly pronounced on the X chromosome. Overall levels of observed genomic heterozygosity did not deviate significantly from simulations based on known population history, giving no support for a general selection for heterozygotes. However, we found evidence supporting balancing selection at a number of loci and also evidence suggesting directional selection at other loci. For markers on chromosome 23, the signal of selection was particularly strong, indicating that purifying selection against deleterious alleles may have occurred even in this very small population. These data suggest that population genomics allows the exploration of the effects of neutral and non-neutral evolution on a finer scale than what has previously been possible.

Place, publisher, year, edition, pages
2009. Vol. 18, no 7, 1341-1351 p.
Keyword [en]
conservation genetics, genome scan, heterozygosity, inbreeding, linkage disequilibrium
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-17700DOI: 10.1111/j.1365-294X.2009.04120.xOAI: diva2:211638
Available from: 2009-04-16 Created: 2009-04-14 Last updated: 2009-04-16

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Hagenblad, Jenny
By organisation
Department of Physics, Chemistry and BiologyThe Institute of Technology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 45 hits
ReferencesLink to record
Permanent link

Direct link