liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Longitudinal one-year study of levels and stoichiometry of neurofilament heavy and light chain concentrations in CSF in patients with multiple system atrophy
University College London.
University College London.
University College London.
University College London.
Show others and affiliations
2009 (English)In: JOURNAL OF THE NEUROLOGICAL SCIENCES, ISSN 0022-510X, Vol. 279, no 1-2, 76-79 p.Article in journal (Refereed) Published
Abstract [en]

Background: Two cerebrospinal fluid (CSF) biomarkers specific for neurodegeneration have recently emerged the neurofilament light (NfL, 68 kDa) and heavy (NfH, 190-210 kDa) chains. This study investigated whether the CSF NfH and NfL levels or their stoichionietric relationship changed over time in a neuroprotective treatment trial.

Methods: Serial CSF samples (n =95) from 42 patients with multiple system atrophy (MSA), half randomized to treatment with recombinant human growth hormone (r-hGH) and the other half to placebo, were collected at baseline, 6 and 12 months. The concentration of CSF NfL and NfH was determined using standard ELISAs. Results: There was no consistent change in the levels of either protein over the 12 month period, or between treatment with active r-hGH versus placebo. The molar stoichiometry of CSF NfL:NfH was 4:1 (R=0.37, p=0.0002) and increased following treatment with r-hGH (p=0.03).

Conclusion: These results indicate that CSF levels of both NfL and NfH on their own are not useful markets of disease progression in MSA, at least over a 12-month period. Future work is needed to elucidate whether the CSF stoichiometry and dynamics of Nf subunits in individual patients are a feature of the underlying pathology and of diagnostic or prognostic value.

Place, publisher, year, edition, pages
2009. Vol. 279, no 1-2, 76-79 p.
Keyword [en]
Neurofilament, Nf heavy chain (NfH), Nf light chain (NfL), Biomarker
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-17701DOI: 10.1016/j.jns.2008.12.037OAI: diva2:211639
Available from: 2009-04-16 Created: 2009-04-14 Last updated: 2009-08-20

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Dizdar-Segrell, Nil
By organisation
Neurology Faculty of Health SciencesDepartment of Neurology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 31 hits
ReferencesLink to record
Permanent link

Direct link