Design and Synthesis of Hydroxyethylene-Based BACE-1 Inhibitors Incorporating Extended P1 Substituents
(English)Manuscript (Other academic)
BACE-1 inhibitors with a hydroxyetylene central core, comprising a methoxy residue in the P1´ position, are presented. Extended P1 substituents were introduced with the aim to explore possible interactions with the S1-S3 pocket. Incorporation of the more advanced P1 substituents produced promising inhibitors in the low micromolar range.
IdentifiersURN: urn:nbn:se:liu:diva-17849OAI: oai:DiVA.org:liu-17849DiVA: diva2:212503