Influence of diazepam on clinically designed FMRI
2007 (English)In: The Journal of Neuropsychiatry and Clinical Neurosciences, ISSN 0895-0172, Vol. 19, no 2, 164-172 p.Article in journal (Refereed) Published
The authors investigated the effect of diazepam on clinically relevant measures from functional magnetic resonance imaging (fMRI) examinations. Twenty volunteers were scanned twice. Using a double-blind randomized study design, the volunteers received placebo on one occasion, and on the other, 5 mg of diazepam. Three functional tests were used: motor, word generation, and working memory. Images were analyzed individually for each subject and the number of activated voxels and the laterality index were calculated. No significant effects related to the drug were detected. In contrast, the motor and working memory tasks showed a significant decrease in the number of activated voxels between Sessions 1 and 2, independently of diazepam administration. These results indicate that diazepam may be administered for premedication prior to fMRI investigations.
Place, publisher, year, edition, pages
2007. Vol. 19, no 2, 164-172 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-17989DOI: 10.1176/appi.neuropsych.19.2.164ISI: 000245666300009PubMedID: 17431063OAI: oai:DiVA.org:liu-17989DiVA: diva2:213948