Editorial: Comparison of apomorphine and levodopa infusions in four patients with Parkinsons disease with symptom fluctuations: in ACTA NEUROLOGICA SCANDINAVICA, ISSN 0001-6314, vol 119, issue 5, pp 345-348
2009 (English)Other (Other academic)
Motor fluctuations in patients with advanced Parkinsons disease may be successfully treated with subcutaneous apomorphine infusion or intraduodenal levodopa/carbidopa infusion. No comparative trials of these two alternatives were performed.
We present a subanalysis from a randomized crossover clinical trial where levodopa infusion as monotherapy was compared with any other combination of pharmacotherapy in fluctuating patients. Four patients used apomorphine infusion and oral levodopa in the comparator arm. The results of these four patients are presented in detail.
The duration of the trial was 3 + 3 weeks. Patients were video-recorded half-hourly on two non-consecutive days of both treatment arms. Blinded video ratings were used. Patient self-assessments of motor function and quality-of-life (QoL) parameters were captured using an electronic diary.
Ratings in moderate to severe off state ranged 0-44% on apomorphine infusion and 0-6% on levodopa infusion. Moderate to severe dyskinesias were not recorded in any of the treatments. QoL was reported to be improved in all patients on duodenal levodopa infusion.
Monotherapy with duodenal infusion of levodopa was more efficacious and brought greater QoL than combination therapy with apomorphine infusion in these fluctuating patients.
Place, publisher, year, edition, pages
2009. Vol. 119, no 5, 345-348 p.
apomorphine, carbidopa, infusion pumps, levodopa, Parkinsons disease
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-18043DOI: 10.1111/j.1600-0404.2008.01104.xOAI: oai:DiVA.org:liu-18043DiVA: diva2:214293