liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Editorial: Comparison of apomorphine and levodopa infusions in four patients with Parkinsons disease with symptom fluctuations: in ACTA NEUROLOGICA SCANDINAVICA, ISSN 0001-6314, vol 119, issue 5, pp 345-348
Uppsala University Hospital.
Sahlgrens University Hospital.
Sahlgrens University Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Neurology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Show others and affiliations
2009 (English)Other (Other academic)
Abstract [en]

Motor fluctuations in patients with advanced Parkinsons disease may be successfully treated with subcutaneous apomorphine infusion or intraduodenal levodopa/carbidopa infusion. No comparative trials of these two alternatives were performed.

We present a subanalysis from a randomized crossover clinical trial where levodopa infusion as monotherapy was compared with any other combination of pharmacotherapy in fluctuating patients. Four patients used apomorphine infusion and oral levodopa in the comparator arm. The results of these four patients are presented in detail.

The duration of the trial was 3 + 3 weeks. Patients were video-recorded half-hourly on two non-consecutive days of both treatment arms. Blinded video ratings were used. Patient self-assessments of motor function and quality-of-life (QoL) parameters were captured using an electronic diary.

Ratings in moderate to severe off state ranged 0-44% on apomorphine infusion and 0-6% on levodopa infusion. Moderate to severe dyskinesias were not recorded in any of the treatments. QoL was reported to be improved in all patients on duodenal levodopa infusion.

Monotherapy with duodenal infusion of levodopa was more efficacious and brought greater QoL than combination therapy with apomorphine infusion in these fluctuating patients.

Place, publisher, year, edition, pages
2009. Vol. 119, no 5, 345-348 p.
Keyword [en]
apomorphine, carbidopa, infusion pumps, levodopa, Parkinsons disease
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-18043DOI: 10.1111/j.1600-0404.2008.01104.xOAI: diva2:214293
Available from: 2009-05-04 Created: 2009-05-04 Last updated: 2010-05-20

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Dizdar-Segrell, Nil
By organisation
Neurology Faculty of Health SciencesDepartment of Neurology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 51 hits
ReferencesLink to record
Permanent link

Direct link