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Comparison of apomorphine and levodopa infusions in four patients with Parkinsons disease with symptom fluctuations
Uppsala University Hospital.
Sahlgrens University Hospital.
Sahlgrens University Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
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2009 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 119, no 5, 345-348 p.Article in journal, Editorial material (Other academic) Published
Abstract [en]

Motor fluctuations in patients with advanced Parkinsons disease may be successfully treated with subcutaneous apomorphine infusion or intraduodenal levodopa/carbidopa infusion. No comparative trials of these two alternatives were performed.

We present a subanalysis from a randomized crossover clinical trial where levodopa infusion as monotherapy was compared with any other combination of pharmacotherapy in fluctuating patients. Four patients used apomorphine infusion and oral levodopa in the comparator arm. The results of these four patients are presented in detail.

The duration of the trial was 3 + 3 weeks. Patients were video-recorded half-hourly on two non-consecutive days of both treatment arms. Blinded video ratings were used. Patient self-assessments of motor function and quality-of-life (QoL) parameters were captured using an electronic diary.

Ratings in moderate to severe off state ranged 0-44% on apomorphine infusion and 0-6% on levodopa infusion. Moderate to severe dyskinesias were not recorded in any of the treatments. QoL was reported to be improved in all patients on duodenal levodopa infusion.

Monotherapy with duodenal infusion of levodopa was more efficacious and brought greater QoL than combination therapy with apomorphine infusion in these fluctuating patients.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2009. Vol. 119, no 5, 345-348 p.
Keyword [en]
apomorphine, carbidopa, infusion pumps, levodopa, Parkinsons disease
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-18043DOI: 10.1111/j.1600-0404.2008.01104.xISI: 000265069900010PubMedID: 18822087Scopus ID: 2-s2.0-64549121148OAI: oai:DiVA.org:liu-18043DiVA: diva2:214293
Available from: 2009-05-04 Created: 2009-05-04 Last updated: 2016-11-03Bibliographically approved

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Dizdar-Segrell, Nil

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