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Smoking as a product of gene-environment interaction
Uppsala University.
Uppsala University.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.
Uppsala University.
2009 (English)In: UPSALA JOURNAL OF MEDICAL SCIENCES, ISSN 0300-9734, Vol. 114, no 2, 100-107 p.Article in journal (Refereed) Published
Abstract [en]

A strong hereditary influence on smoking has been demonstrated. As one of the candidate genes in relation to smoking, the serotonin transporter gene (5-HTTLPR) has been suggested, however with conflicting results. In recent studies, it has been shown that genotypic and environmental (G*E) factors interact in the shaping of a variety of phenotypic expressions. The objective of the present study was to investigate the interaction between a variation in the 5-HTTLPR and family environment in relation to smoking habits, nicotine dependence, and nicotine and cotinine levels in hair samples. A random Swedish adolescent population sample (n = 785), from which 200 individuals were stratified regarding behaviour, was genotyped for 5-HTTLPR and assessed with semi-structured interviews, a questionnaire, and hair analyses of nicotine and cotinine. The 5-HTTLPR gene interacted with a poor family environment to predict smoking habits, as well as nicotine and cotinine levels. The risk of being a smoker was increased 13 times for an individual with a combination of the 5-HTTLPR LS genotype and a poor family environment in comparison with the Homozygous Long-Long (LL) genotype and a good family environment.

Place, publisher, year, edition, pages
2009. Vol. 114, no 2, 100-107 p.
Keyword [en]
Adolescents, cotinine, environment, gene, nicotine, serotonin, smoking
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-18132DOI: 10.1080/03009730902833406OAI: diva2:216421
Available from: 2009-05-08 Created: 2009-05-08 Last updated: 2014-01-09Bibliographically approved

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Kronstrand, Robert
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