Plasma Levels of Matrix Metalloproteinase-9 are Independently Associated With Psychosocial Factors in a Middle-Aged Normal Population
2009 (English)In: PSYCHOSOMATIC MEDICINE, ISSN 0033-3174, Vol. 71, no 3, 292-300 p.Article in journal (Refereed) Published
Objective: To test the association between psychosocial factors and circulating levels of matrix metalloproteinase-9 (MMP-9) in a normal population sample. Psychosocial factors have been associated with inflammatory markers and are of prognostic significance for coronary artery disease (CAD). The degrading enzyme MMP-9 is upregulated in inflammatory processes and hypothesized to play a role in the rupture of atherosclerotic plaques. Methods: A total of 402 participants (50% women), aged 45 to 69 years, were drawn randomly from a normal population. Psychosocial instruments covered depression (Center for Epidemiological Studies Depression Questionnaire, CES-D), vital exhaustion, hostile affect, cynicism, mastery, self-esteem, sense of coherence (SOC), emotional support, and social integration. Plasma MMP-9 was measured by an enzyme-linked immunosorbent assay method. Linear regression models were adjusted for age, sex, known CAD, rheumatoid arthritis, cancer, cardiovascular risk factors including C-reactive protein and ongoing medication. Results: After full adjustment, there were independent associations of elevated MMP-9 levels with CES-D (+2.9 ng/ml per SD, p=.02), hostile affect (+3.0 ng/ml per SD, p=.02), cynicism (+3.5 ng/ml per SD, p=.006), and SOC (-2.5 ng/ml per SD, p=.046). A principal component analysis extracted three components. The first was mainly extracted from CES-D, vital exhaustion, self-esteem, mastery, and SOC; the second was mainly extracted from hostile affect and cynicism. Both were independently associated with MMP-9 (p=.02, p=.04) when run in the same model. Conclusions: MMP-9 levels were associated with psychosocial factors in a middle-aged normal population sample, independently of traditional risk factors. The findings may constitute a possible link between psychosocial factors and cardiovascular risk.
Place, publisher, year, edition, pages
2009. Vol. 71, no 3, 292-300 p.
depression, hostile affect, cynicism, sense of coherence, metalloproteinases, cardiovascular
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-18140DOI: 10.1097/PSY.0b013e3181960e7fOAI: oai:DiVA.org:liu-18140DiVA: diva2:216479
This is a non-final version of an article published in final form:
Peter Garvin, Lennart Nilsson, John Carstensen, Lena Jonasson and Margareta Kristenson , Plasma Levels of Matrix Metalloproteinase-9 are Independently Associated With Psychosocial Factors in a Middle-Aged Normal Population, 2009, PSYCHOSOMATIC MEDICINE, (71), 3, 292-300.
Copyright: Lippincott, Williams & Wilkins