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Delayed Mustard Gas Keratitis: Clinical Course and In Vivo Confocal Microscopy Findings
Linköping University, Department of Clinical and Experimental Medicine, Ophthalmology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of Ophthalmology UHL/MH.
Linköping University, Department of Clinical and Experimental Medicine, Ophthalmology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of Ophthalmology UHL/MH.
2009 (English)In: CORNEA, ISSN 0277-3740, Vol. 28, no 4, 458-462 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To report the detailed clinical and in vivo confocal microscopic findings in a patient with delayed-onset mustard gas keratitis observed 20 years after initial exposure.

Methods: A 38-year-old man who was exposed to mustard gas in Iraq at the age of 19 years was examined after presenting with ocular symptoms 17 years after initial recovery from the exposure. Slit-lamp biomicroscopy, corneal topography, and in vivo confocal microscopy were performed on both corneas.

Results: The clinical symptoms were consistent with a delayed form of mustard gas keratitis, although the patient had clear central corneas and good visual acuity. Confocal microscopic findings included evidence of epithelial abnormalities, necrotic changes in the anterior stroma, subbasal and anterior stromal nerve proliferation, and deep stromal keratocyte activation.

Conclusions: In vivo confocal microscopy revealed persistent morphologic abnormalities in the anterior stroma of both corneas 20 years after initial exposure to mustard gas. The detection of a population of dendritic cell bodies in the central epithelium and evidence of keratocyte activation and migration in the deep stroma indicated the presence of ongoing subclinical processes.

Place, publisher, year, edition, pages
LWW , 2009. Vol. 28, no 4, 458-462 p.
Keyword [en]
cornea, confocal microscopy, mustard gas injury, delayed keratitis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-18288DOI: 10.1097/ICO.0b013e31818a7dd0OAI: oai:DiVA.org:liu-18288DiVA: diva2:217863
Note
Original Publication: Neil Lagali and Per Fagerholm, Delayed Mustard Gas Keratitis: Clinical Course and In Vivo Confocal Microscopy Findings, 2009, CORNEA, (28), 4, 458-462. http://dx.doi.org/10.1097/ICO.0b013e31818a7dd0 Copyright: Lippincott Williams & Wilkins http://www.lww.com/ Available from: 2009-05-17 Created: 2009-05-15 Last updated: 2011-02-24

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