Water Flux in Cell Motility: Expanding the Mechanisms of Membrane Protrusion
2009 (English)In: CELL MOTILITY AND THE CYTOSKELETON, ISSN 0886-1544, Vol. 66, no 5, 237-247 p.Article, review/survey (Refereed) Published
Transmembrane water fluxes through aquaporins (AQPs) are suggested to play, pivotal roles in cell polarization and directional cell motility. Local dilution by W water influences the dynamics of the subcortical actin polymerization and directs the formation of nascent membrane protrusions. In this paper. recent evidence is discussed in support of such a central role of AQP in membrane protrusion formation, and cell migration as a basis for our Understanding AQP9 Underlying molecular mechanisms of directional motility. Specifically. AQP9 in a physiological context controls transmembrane water fluxes driving, membrane protrusion formation, as an initial cellular response to a chemoattractant or other migratory signals. The importance of AQP-facilitated water fluxes in directional cell motility is underscored the observation that blocking or modifying specific sites in AQP9 also interferes with the molecular machinery that govern actin-mediated cellular shape changes. Cell Motil.
Place, publisher, year, edition, pages
2009. Vol. 66, no 5, 237-247 p.
aquaporins, cell motility, polarity, morphology, filopodia
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-18290DOI: 10.1002/cm.20357OAI: oai:DiVA.org:liu-18290DiVA: diva2:217865