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The Acupuncture on Hot Flushes Among Menopausal Women (ACUFLASH) study, a randomized controlled trial
University of Tromso.
University of Tromso.
University of Exeter.
University of Tromso.
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2009 (English)In: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, ISSN 1072-3714, Vol. 16, no 3, 484-493 p.Article in journal (Refereed) Published
Abstract [en]

Objective: This study compared the effectiveness of individualized acupuncture plus self-care versus self-care alone on hot flashes and health-related quality of life in postmenopausal women.

Methods: This study involved a multicenter, pragmatic, randomized, controlled trial with two parallel arms. Participants were postmenopausal women experiencing, on average, seven or more hot flashes per 24 hours during seven consecutive days. The acupuncture group received 10 acupuncture treatment sessions and advice on self-care, and the control group received advice on self-care only. The frequency and severity (0-10 scale) of hot flashes were registered in a diary. Urine excretion of calcitonin gene-related peptide was assessed at baseline and after 12 weeks. The primary endpoint was change in mean hot flash frequency from baseline to 12 weeks. The secondary endpoint was change in health-related quality of life measured by the Womens Health Questionnaire.

Results: Hot flash frequency decreased by 5.8 per 24 hours in the acupuncture group (n = 134) and 3.7 per 24 hours in the control group (n = 133), a difference of 2.1 (P < 0.001). Hot flash intensity decreased by 3.2 units in the acupuncture group and 1.8 units in the control group, a difference of 1.4 (P < 0.001). The acupuncture group experienced statistically significant improvements in the vasomotor, sleep, and somatic symptoms dimensions of the Womens Health Questionnaire compared with the control group. Urine calcitonin gene-related peptide excretion remained unchanged from baseline to week 12.

Conclusions: Acupuncture plus self-care can contribute to a clinically relevant reduction in hot flashes and increased health-related quality of life in postmenopausal women.

Place, publisher, year, edition, pages
2009. Vol. 16, no 3, 484-493 p.
Keyword [en]
Acupuncture, Menopause, Hot flash
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-18551DOI: 10.1097/gme.0b013e31818c02adOAI: diva2:220580
Available from: 2009-06-01 Created: 2009-06-01 Last updated: 2009-08-17

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Hammar, MatsLindh-Åstrand, LottaTheodorsson, Elvar
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Obstetrics and gynecology Faculty of Health SciencesDepartment of Gynecology and Obstetrics in LinköpingClinical ChemistryDepartment of Clinical Chemistry
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