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Experimental results of combining bisphosphonates with allograft in a rat model
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2009 (English)In: Journal of Bone and Joint Surgery - Series B, ISSN 0301-620X, Vol. 91, no 5, 670-675 p.Article in journal (Refereed) Published
Abstract [en]

Soaking bone grafts in a bisphosphonate solution before implantation can prevent their resorption and increase the local bone density in rats and humans. However, recent studies suggest that pre-treatment of allografts with bisphosphonate can prevent bone ingrowth into impaction grafts. We tested the hypothesis that excessive amounts of bisphosphonate would also cause a negative response in less dense grafts. We used a model where nonimpacted metaphyseal bone grafts were randomised into three groups with either no bisphosphonate, alendronate followed by rinsing, and alendronate without subsequent rinsing, and inserted into bone chambers in rats. The specimens were evaluated histologically at one week, and by histomorphometry and radiology at four weeks. At four weeks, both bisphosphonate groups showed an increase in the total bone content, increased newly formed bone, and higher radiodensity than the controls. In spite of being implanted in a chamber with a limited opportunity to diffuse, even an excessive amount of bisphosphonate improved the outcome. We suggest that the negative results seen by others could be due to the combination of densely compacted bone and a bisphosphonate. We suggest that bisphosphonates are likely to have a negative influence where resorption is a prerequisite to create space for new bone ingrowth.

Place, publisher, year, edition, pages
2009. Vol. 91, no 5, 670-675 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-18752DOI: 10.1302/0301-620X.91B5.21867OAI: oai:DiVA.org:liu-18752DiVA: diva2:221292
Available from: 2009-06-03 Created: 2009-06-03 Last updated: 2009-08-17

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Agholme, FredrikAspenberg, Per

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Orthopaedics and Sports Medicine Faculty of Health SciencesDepartment of Orthopaedics Linköping
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CiteExportLink to record
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  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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  • Other style
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Language
  • de-DE
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  • nn-NB
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Output format
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