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Advantages of standardized criteria for the interpretation of angiotensin-converting enzyme inhibition renography
Lund University.
Malmö University.
Linköping University, Department of Medicine and Health Sciences, Clinical Physiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
2009 (English)In: NUCLEAR MEDICINE COMMUNICATIONS, ISSN 0143-3636, Vol. 30, no 6, 449-454 p.Article in journal (Refereed) Published
Abstract [en]

Background The aim of this study was to evaluate the efficiency of captopril renography to detect renovascular hypertension (RVH) using the standardized test criteria established at the consensus conference in Santa Fe 1995. The evaluation was made prospectively and in a clinical situation.less thanpgreater thanMethods Renal scintigraphy was performed with Tc-99m-MAG3 according to a 2-day protocol in patients receiving 25 mg captopril 1 h before the test. A baseline study was added only in patients showing abnormal findings in the captopril-stimulated study. All tests were re-evaluated according to the consensus criteria by two nuclear medicine specialists who were unaware of the original evaluation that was made by different doctors on duty at the nuclear medicine section at the time.less than/pgreater than less thanpgreater thanResults Using a 12-month clinical follow-up as a reference, 16 patients in a group of 164 hypertensive patients had RVH, that is, a prevalence of 10%. The re-evaluation and original evaluation indicated a sensitivity of 94 versus 100%, specificity of 97 versus 88%, accuracy of 97 versus 89%, positive predictive value of 83 versus 47%, and negative predictive value of 99 versus 100%. In 15 studies, results from the two evaluations were discordant and in 14 of these studies an originally false positive or intermediate study was re-evaluated as negative. The test result was highly decisive in the future management of patients, minimizing the number of renal angiograms that had to be performed and initiating a search for other causes of secondary hypertension.

Conclusion Captopril renography is a useful and reliable test in patients with suspicion of RVH. Strict adherence to the diagnostic criteria and recommendations from the 1995 consensus conference further improved the performance of the test compared with clinical follow-up.

Place, publisher, year, edition, pages
2009. Vol. 30, no 6, 449-454 p.
Keyword [en]
atherosclerotic renovascular disease, blood pressure response to acute angiotensin-converting enzyme inhibition, captopril renography, outcome, renal artery stenosis, renovascular hypertension
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-18902DOI: 10.1097/MNM.0b013e328329fdd7OAI: diva2:222101
Available from: 2009-06-05 Created: 2009-06-05 Last updated: 2009-08-21

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Granerus, Göran
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Clinical Physiology Faculty of Health SciencesDepartment of Clinical Physiology
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ReferencesLink to record
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