liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Improving the efficacy of cancer immunotherapy
St Georges University.
St Georges University.
Leiden University.
Argos Therapeut.
Show others and affiliations
2009 (English)In: EUROPEAN JOURNAL OF CANCER, ISSN 0959-8049, Vol. 45, no 8, 1424-1431 p.Article in journal (Refereed) Published
Abstract [en]

A series of cancer vaccines have been evaluated in clinical trials with encouraging results, but the demonstration of clinical benefit in confirmatory studies has so far proven to be difficult. The development of cancer vaccines is hampered by a range of issues particular to this field of research. On 12th March 2008, the Biotherapy Development Association convened a workshop to discuss issues faced by scientists and clinicians involved in the development of cancer vaccines. This paper is a review of the field, based on discussions held at the BDA workshop, and describes biological barriers encountered in generating effective immune responses to tumours, methodological obstacles encountered in the improvement of immunological monitoring which aims to improve inter-laboratory and inter-trial comparisons, challenges in clinical trial design and problems posed by the lack of specific regulation for cancer vaccines and the impact on their development. Ultimately, a number of general solutions are posed: (1) better patient selection, (2) use of multi-modal treatments that affect several aspects of the immune system at once, (3) a requirement for the development of good biomarkers to stratify patients for selection prior to trial and as surrogates for clinical response and (4) harmonisation of SOPs for immunological monitoring of clinical trials.

Place, publisher, year, edition, pages
2009. Vol. 45, no 8, 1424-1431 p.
Keyword [en]
Immunotherapy, Cancer vaccine, Clinical response, Immunological monitoring, Combination therapy, Immunosupression, End-points, Surrogate end-points
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-19404DOI: 10.1016/j.ejca.2008.12.017OAI: diva2:224925
Available from: 2009-06-23 Created: 2009-06-22 Last updated: 2010-05-24

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Department of Oncology UHL
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 30 hits
ReferencesLink to record
Permanent link

Direct link