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Septic shock and the lysosomal-mitochondrial axis theory of apoptosis
Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
Experimental Vascular Research Unit, Clinical Research Center, Lund University.
2009 (English)In: Molecular Mechanism of Severe Shock, Kerala, India: Research Signpost , 2009, 91-106 p.Chapter in book (Other academic)
Abstract [en]

Over 250 years ago, Le Dran, a distinguished French Surgeon, first used the word “shock” in his treatise. Since then, much progress has been made in shock research. However, many questions have still confused the medical doctors until now. For example, why the reduced blood pressure can’t return to normal after anti-shock treatment in severe shock, why the high mortality of septic shock can’t be reduced though many new therapies are reported, what is the reason for the development of systemic inflammatory response syndrome and multiple organ dysfunction syndrome following a prolonged severe shock, and what event triggers the connection among shock, systemic inflammation, and multi-organ dysfunction, etc. In order to resolve these questions, research on the pathogenesis of shock has been made at molecular level in recent years. Current advances of shock molecular mechanism are presented in this book, which is divided into 10 chapters, including new theory about auto-digestion in shock and organ failure, septic shock and the lysosomal-mitochondrial axis theory in apoptosis, molecular mechanism of endotoxin action, HMGB-1 and sepsis after burns, role of MAPK in inflammation and septic shock, ion channels and low vasoreactivity in severe shock, vascular permeability in shock, lymphatic microcirculation and shock, calcium signaling in cardiac dysfunction of burns, the effect and mechanism of a new anti-shock medicine Polydatin. We hope that these chapters will help the readers to develop strategies and tactics that will promote shock research. We want to thank all the authors for their excellent cooperation and manuscript preparation. We also give special thanks to Dr. Pandalai for inviting us to edit and publish this review book in Research Signpost


Place, publisher, year, edition, pages
Kerala, India: Research Signpost , 2009. 91-106 p.
Keyword [en]
apoptosis, lysosomes, septic shock
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-19471ISBN: 978-81-308-0338-8OAI: diva2:225103
Available from: 2009-06-24 Created: 2009-06-24 Last updated: 2013-04-30Bibliographically approved

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Brunk, Ulf
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