Feeding-related immune responsive brain stem neurons: association with CGRP
2001 (English)In: Neuroreport, ISSN 0959-4965 (print) 1473-558X (online), Vol. 12, no 11, 2399-2403 p.Article in journal (Refereed) Published
Using dual-labeling in situ hybridization histochemistry, the neurotransmitter expression of immune-responsive neurons in the pontine parabrachial nucleus, a major relay for interoceptive information, was investigated. Intravenous injection of bacterial wall lipopolysaccharide resulted in dense c-fos mRNA expression in the external lateral parabrachial nucleus, and a majority of the c-fos expressing cells also expressed calcitonin gene-related peptide (CGRP) mRNA. In contrast CGRP-posi- tive cells in the adjoining external medial subnucleus were c-fos negative. Taken together with previous hodological and behavioral studies, these data suggest that CGRPergic parabrachial neurons may mediate lipopolysaccharide-induced anorexia by means of their projection to central nucleus of the amygdala.
Place, publisher, year, edition, pages
2001. Vol. 12, no 11, 2399-2403 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-14081ISI: 000170141600024OAI: oai:DiVA.org:liu-14081DiVA: diva2:22590