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Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure
Uppsala University.
Uppsala University.
Uppsala University.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
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2008 (English)In: EXPERIMENTAL DIABETES RESEARCH, ISSN 1687-5214, Vol. 2008, no 562985Article in journal (Refereed) Published
Abstract [en]

Following the encouraging report of the Edmonton group, there was a rejuvenation of the islet transplantation field. After that, more pessimistic views spread when long-term results of the clinical outcome were published. A progressive loss of the beta-cell function meant that almost all patients were back on insulin therapy after 5 years. More than 10 years ago, we demonstrated that amyloid deposits rapidly formed in human islets and in mouse islets transgenic for human IAPP when grafted into nude mice. It is, therefore, conceivable to consider amyloid formation as one potential candidate for the long-term failure. The present paper reviews attempts in our laboratories to elucidate the dynamics of and mechanisms behind the formation of amyloid in transplanted islets with special emphasis on the impact of long-term hyperglycemia.

Place, publisher, year, edition, pages
2008. Vol. 2008, no 562985
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-19671DOI: 10.1155/2008/562985OAI: oai:DiVA.org:liu-19671DiVA: diva2:227298
Note
Original Publication: Arne Andersson, Sara Bohman, L A Hakan Borg, Johan Paulsson, Sebastian Schultz, Gunilla Westermark and Per Westermark, Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure, 2008, EXPERIMENTAL DIABETES RESEARCH, (2008), 562985. http://dx.doi.org/10.1155/2008/562985 Copyright: Authors Available from: 2009-08-28 Created: 2009-07-10 Last updated: 2009-08-28Bibliographically approved

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Paulsson, JohanSchultz, SebastianWestermark, Gunilla

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