liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure
Uppsala University.
Uppsala University.
Uppsala University.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Show others and affiliations
2008 (English)In: EXPERIMENTAL DIABETES RESEARCH, ISSN 1687-5214, Vol. 2008, no 562985Article in journal (Refereed) Published
Abstract [en]

Following the encouraging report of the Edmonton group, there was a rejuvenation of the islet transplantation field. After that, more pessimistic views spread when long-term results of the clinical outcome were published. A progressive loss of the beta-cell function meant that almost all patients were back on insulin therapy after 5 years. More than 10 years ago, we demonstrated that amyloid deposits rapidly formed in human islets and in mouse islets transgenic for human IAPP when grafted into nude mice. It is, therefore, conceivable to consider amyloid formation as one potential candidate for the long-term failure. The present paper reviews attempts in our laboratories to elucidate the dynamics of and mechanisms behind the formation of amyloid in transplanted islets with special emphasis on the impact of long-term hyperglycemia.

Place, publisher, year, edition, pages
2008. Vol. 2008, no 562985
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-19671DOI: 10.1155/2008/562985OAI: diva2:227298
Original Publication: Arne Andersson, Sara Bohman, L A Hakan Borg, Johan Paulsson, Sebastian Schultz, Gunilla Westermark and Per Westermark, Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure, 2008, EXPERIMENTAL DIABETES RESEARCH, (2008), 562985. Copyright: Authors Available from: 2009-08-28 Created: 2009-07-10 Last updated: 2009-08-28Bibliographically approved

Open Access in DiVA

fulltext(1852 kB)233 downloads
File information
File name FULLTEXT01.pdfFile size 1852 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Paulsson, JohanSchultz, SebastianWestermark, Gunilla
By organisation
Cell BiologyFaculty of Health Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 233 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 79 hits
ReferencesLink to record
Permanent link

Direct link