Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic
2009 (English)In: BIOORGANIC and MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, Vol. 19, no 16, 4711-4714 p.Article in journal (Refereed) Published
Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized. The most potent inhibitor exhibited a BACE-1 IC50 value of 0.23 mu M.
Place, publisher, year, edition, pages
2009. Vol. 19, no 16, 4711-4714 p.
Alzheimers disease, BACE-1, Enzyme inhibitor, Transition state mimetic
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-19803DOI: 10.1016/j.bmcl.2009.06.065OAI: oai:DiVA.org:liu-19803DiVA: diva2:229059