liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic
Uppsala University.
Uppsala University.
Uppsala University.
Linköping University, Department of Physics, Chemistry and Biology, Organic Chemistry . Linköping University, The Institute of Technology.
Show others and affiliations
2009 (English)In: BIOORGANIC and MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, Vol. 19, no 16, 4711-4714 p.Article in journal (Refereed) Published
Abstract [en]

Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized. The most potent inhibitor exhibited a BACE-1 IC50 value of 0.23 mu M.

Place, publisher, year, edition, pages
2009. Vol. 19, no 16, 4711-4714 p.
Keyword [en]
Alzheimers disease, BACE-1, Enzyme inhibitor, Transition state mimetic
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-19803DOI: 10.1016/j.bmcl.2009.06.065OAI: oai:DiVA.org:liu-19803DiVA: diva2:229059
Available from: 2009-08-11 Created: 2009-08-10 Last updated: 2009-08-11

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Rosenquist, Åsa

Search in DiVA

By author/editor
Rosenquist, Åsa
By organisation
Organic Chemistry The Institute of Technology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 35 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf