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Optical measurements during experimental stereotactic radiofrequency lesioning
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0001-8661-2232
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)ORCID iD: 0000-0002-0012-7867
2006 (English)In: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 84, no 2-3, 118-124 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to evaluate in vivo a laser Doppler measurement system in porcine brain tissue during thermal lesioning. A 2-mm monopolar radiofrequency lesioning electrode was equipped with optical fibers in order to monitor the lesioning procedure. Laser Doppler and backscattered light intensity signals were measured along the electrode trajectory and during bilateral lesioning in the central gray (70, 80 and 90°C, n = 14). The time course of the coagulation process could be followed by optical recordings. Two separate groups of tissue were identified from the intensity signals. The changes in the perfusion levels in both groups displayed significant changes (p < 0.05, n = 48) at all temperature settings, while backscattered light intensity was significant for only one group at the different temperatures (p < 0.05, n = 39). These results indicate that optical measurements correlate with lesion development in vivo. The study also indicates that it is possible to follow the lesioning process intra-operatively.

Place, publisher, year, edition, pages
S. Karger, 2006. Vol. 84, no 2-3, 118-124 p.
Keyword [en]
Laser Doppler, Radiofrequency lesioning, Functional neurosurgery, Brain electrodes
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:liu:diva-14233DOI: 10.1159/000094463ISI: 000239562300010PubMedID: 16840822Scopus ID: 2-s2.0-33746647435OAI: oai:DiVA.org:liu-14233DiVA: diva2:22960
Available from: 2007-01-26 Created: 2007-01-26 Last updated: 2017-12-13Bibliographically approved
In thesis
1. On optical methods for intracerebral measurements during stereotactic and functional neurosurgery: Experimental studies
Open this publication in new window or tab >>On optical methods for intracerebral measurements during stereotactic and functional neurosurgery: Experimental studies
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Radio frequency (RF) lesioning and deep brain stimulation (DBS) are the two prevailing surgical treatments for movement disorders within the field of stereotactic and functional neurosurgery. For RF-lesioning, a small volume of brain tissue is coagulated and knowledge of the lesion size and growth is of great importance for the safety and outcome of the procedure. This thesis deals with adapting the laser Doppler perfusion monitoring (LDPM) technique for measurements in brain tissue during RF-lesioning. The relation between LDPM signal changes and developed lesion size was investigated. LDPM measurements were evaluated both in vitro (albumin protein solution) and in vivo in the porcine brain during RF-lesioning corresponding to a bilateral thalamotomy in man. The investigated signals from the LDPI measurements can be used for following the lesioning time course and to detect if a lesion was created, both in vitro and in the animal model. For the albumin model, both the total backscattered light intensity and the perfusion signal can be used as markers for estimating the final coagulation size, while in the animal model this conclusion was not statistical verified.

Independent on surgical method, RF-lesioning or DBS, intracerebral guidance is an important aspect within stereotactic and functional neurosurgery. To increase the accuracy and precision of reaching the correct target, different methods for intracerebral guidance exist, such as microelectrode recording and impedance methods. In this thesis, the possibility of developing an optical intracerebral guidance method has been investigated. Diffuse reflectance spectroscopy served as technology and all measurements were performed stereotactically in both porcine and human brain. Measurements of white and gray matter showed large differences, with higher reflectivity for white brain matter, both in porcine and in human brain. For the human measurements during DBS-implants, large differences between white matter and functional targets were found. Additionally, differences between native and lesioned porcine brain matter were detected. Both studies support the idea of using diffuse reflectance spectroscopy for developing an intracerebral guidance method.

Place, publisher, year, edition, pages
Institutionen för medicinsk teknik, 2007
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1070
Keyword
Laser Doppler perfusion monitoring, Diffuse reflectance spectroscopy, Functional and stereotactic neurosurgery
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:liu:diva-8081 (URN)978-91-85715-91-6 (ISBN)
Public defence
2007-02-02, Elsa Brändströms sal, Södra Entreén, Universitetssjukhuset, Linköping, 09:15 (English)
Opponent
Supervisors
Available from: 2007-01-26 Created: 2007-01-26 Last updated: 2016-05-04

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Antonsson, JohanEriksson, OlaLundberg, PeterWårdell, Karin

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