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In vitro measurements of optical properties of porcine brain using a novel compact device
Department of Physics, Lund Institute of Technology, Lund, Sweden.
National Laser Centre, CSIR, Pretoria, South Africa.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)ORCID iD: 0000-0002-0012-7867
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2005 (English)In: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 43, no 5, 658-666 p.Article in journal (Refereed) Published
Abstract [en]

Knowledge of the optical properties of tissues can be applied in numerous medical and scientific fields, including cancer diagnostics and therapy. There are many different ways of determining the optical properties of turbid media. The paper describes measurements of the optical properties of porcine brain tissue using novel instrumentation for simultaneous absorption and scattering characterisation of small turbid samples. Integrating sphere measurements are widely used as a reference method for determination of the optical properties of relatively thin turbid samples. However, this technique is associated with bulky equipment, complicated measuring techniques, interference compensation techniques and inconvenient sample handling. It is believed that the sphere for some applications can be replaced by a new, compact device, called the combined angular and spatially resolved head sensor, to measure the optical properties of thin turbid samples. The results compare very well with data obtained with an integrating sphere for well-defined samples. The instrument was shown to be accurate to within 12% for μa and 1% for μ s in measurements of intralipid-ink samples. The corresponding variations of data were 17% and 2%, respectively. The reduced scattering coefficient for porcine white matter was measured to be 100 cm−1 at 633 nm, and the value for coagulated brain tissue was 65 cm−1. The corresponding absorption coefficients were 2 and 3 cm−1, respectively.

Place, publisher, year, edition, pages
Springer, 2005. Vol. 43, no 5, 658-666 p.
Keyword [en]
Optical properties, Turbid media, Integrating sphere, CASH sensor, Porcine brain tissue, Scattering
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-14236DOI: 10.1007/BF02351040ISI: 000234262300016Scopus ID: 2-s2.0-29244462497OAI: oai:DiVA.org:liu-14236DiVA: diva2:22963
Available from: 2007-01-26 Created: 2007-01-26 Last updated: 2017-02-21Bibliographically approved
In thesis
1. On optical methods for intracerebral measurements during stereotactic and functional neurosurgery: Experimental studies
Open this publication in new window or tab >>On optical methods for intracerebral measurements during stereotactic and functional neurosurgery: Experimental studies
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Radio frequency (RF) lesioning and deep brain stimulation (DBS) are the two prevailing surgical treatments for movement disorders within the field of stereotactic and functional neurosurgery. For RF-lesioning, a small volume of brain tissue is coagulated and knowledge of the lesion size and growth is of great importance for the safety and outcome of the procedure. This thesis deals with adapting the laser Doppler perfusion monitoring (LDPM) technique for measurements in brain tissue during RF-lesioning. The relation between LDPM signal changes and developed lesion size was investigated. LDPM measurements were evaluated both in vitro (albumin protein solution) and in vivo in the porcine brain during RF-lesioning corresponding to a bilateral thalamotomy in man. The investigated signals from the LDPI measurements can be used for following the lesioning time course and to detect if a lesion was created, both in vitro and in the animal model. For the albumin model, both the total backscattered light intensity and the perfusion signal can be used as markers for estimating the final coagulation size, while in the animal model this conclusion was not statistical verified.

Independent on surgical method, RF-lesioning or DBS, intracerebral guidance is an important aspect within stereotactic and functional neurosurgery. To increase the accuracy and precision of reaching the correct target, different methods for intracerebral guidance exist, such as microelectrode recording and impedance methods. In this thesis, the possibility of developing an optical intracerebral guidance method has been investigated. Diffuse reflectance spectroscopy served as technology and all measurements were performed stereotactically in both porcine and human brain. Measurements of white and gray matter showed large differences, with higher reflectivity for white brain matter, both in porcine and in human brain. For the human measurements during DBS-implants, large differences between white matter and functional targets were found. Additionally, differences between native and lesioned porcine brain matter were detected. Both studies support the idea of using diffuse reflectance spectroscopy for developing an intracerebral guidance method.

Place, publisher, year, edition, pages
Institutionen för medicinsk teknik, 2007
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1070
Keyword
Laser Doppler perfusion monitoring, Diffuse reflectance spectroscopy, Functional and stereotactic neurosurgery
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:liu:diva-8081 (URN)978-91-85715-91-6 (ISBN)
Public defence
2007-02-02, Elsa Brändströms sal, Södra Entreén, Universitetssjukhuset, Linköping, 09:15 (English)
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Available from: 2007-01-26 Created: 2007-01-26 Last updated: 2016-05-04

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Antonsson, JohanWårdell, Karin

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