Potent inhibitors of the hepatitis C virus NS3 protease: use of a novel P2 cyclopentane-derived template
2006 (English)In: Bioorganic & Medicinal Chemistry, ISSN 0968-0896, E-ISSN 1464-3391, Vol. 14, no 15, 5136-5151 p.Article in journal (Refereed) Published
The HCV NS3 protease is essential for replication of the hepatitis C virus (HCV) and therefore constitutes a promising new drug target for anti-HCV therapy. Several potent and promising HCV NS3 protease inhibitors, some of which display low nanomolar activities, were identified from a series of novel inhibitors incorporating a trisubstituted cyclopentane dicarboxylic acid moiety as a surrogate for the widely used N-acyl-(4R)-hydroxyproline in the P2 position.
Place, publisher, year, edition, pages
2006. Vol. 14, no 15, 5136-5151 p.
HCV, NS3, Protease inhibitor, Cyclopentane-derived P2 scaffold
National CategoryNatural Sciences
IdentifiersURN: urn:nbn:se:liu:diva-14308DOI: 10.1016/j.bmc.2006.04.008OAI: oai:DiVA.org:liu-14308DiVA: diva2:23195