Genetic basis of host resistance to norovirus infection
2009 (English)In: FUTURE VIROLOGY, ISSN 1746-0794, Vol. 4, no 4, 369-382 p.Article in journal (Refereed) Published
Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages and are responsible for 200,000 deaths every year, mainly in developing countries. Despite high infectivity and lack of long-term immunity, authentic and volunteer studies have shown existence of inherited protective factors. Recent studies have shown that secretor status controlled by the alpha(1,2)-fucosyltransferase gene located on chromosome 19 determines susceptibility to most, if not all, norovirus infections, with individuals homozygous for the G428A nonsense mutation (nonsecretors) representing 20% of the highly protected European population.
Place, publisher, year, edition, pages
2009. Vol. 4, no 4, 369-382 p.
gastroenteritis; histo-blood group antigens; host genetics; norovirus; secretor status; susceptibility; viral evolution
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-20140DOI: 10.2217/fvl.09.14OAI: oai:DiVA.org:liu-20140DiVA: diva2:233394