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Genetic basis of host resistance to norovirus infection
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
2009 (English)In: FUTURE VIROLOGY, ISSN 1746-0794, Vol. 4, no 4, 369-382 p.Article, review/survey (Refereed) Published
Abstract [en]

Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages and are responsible for 200,000 deaths every year, mainly in developing countries. Despite high infectivity and lack of long-term immunity, authentic and volunteer studies have shown existence of inherited protective factors. Recent studies have shown that secretor status controlled by the alpha(1,2)-fucosyltransferase gene located on chromosome 19 determines susceptibility to most, if not all, norovirus infections, with individuals homozygous for the G428A nonsense mutation (nonsecretors) representing 20% of the highly protected European population.

Place, publisher, year, edition, pages
2009. Vol. 4, no 4, 369-382 p.
Keyword [en]
gastroenteritis; histo-blood group antigens; host genetics; norovirus; secretor status; susceptibility; viral evolution
National Category
Infectious Medicine Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-20140DOI: 10.2217/fvl.09.14ISI: 000268120000012OAI: oai:DiVA.org:liu-20140DiVA: diva2:233394
Available from: 2009-08-31 Created: 2009-08-31 Last updated: 2017-01-16

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Kindberg, ElinSvensson, Lennart

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