liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
ETH.
Salk Institute of Biological Studies.
University of California.
ETH.
Show others and affiliations
2009 (English)In: SCIENCE, ISSN 0036-8075, Vol. 325, no 5938, 328-332 p.Article in journal (Refereed) Published
Abstract [en]

Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimers disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.

Place, publisher, year, edition, pages
2009. Vol. 325, no 5938, 328-332 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-20157DOI: 10.1126/science.1173155OAI: oai:DiVA.org:liu-20157DiVA: diva2:233668
Available from: 2009-09-01 Created: 2009-08-31 Last updated: 2015-05-28

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Nilsson, PeterSimon, Rozalyn

Search in DiVA

By author/editor
Nilsson, PeterSimon, Rozalyn
By organisation
Organic ChemistryThe Institute of TechnologyChemistryFaculty of Science & Engineering
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 1333 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf