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Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
Salk Institute of Biological Studies.
University of California.
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2009 (English)In: SCIENCE, ISSN 0036-8075, Vol. 325, no 5938, 328-332 p.Article in journal (Refereed) Published
Abstract [en]

Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimers disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.

Place, publisher, year, edition, pages
2009. Vol. 325, no 5938, 328-332 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-20157DOI: 10.1126/science.1173155OAI: diva2:233668
Available from: 2009-09-01 Created: 2009-08-31 Last updated: 2015-05-28

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Nilsson, PeterSimon, Rozalyn
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