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The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) Trial: clinical rationale, study design, and implementation
Gentofte University Hospital.
Skejby University Hospital.
Gentofte University Hospital.
Leipzig University Hospital.
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2009 (English)In: EUROPACE, ISSN 1099-5129, Vol. 11, no 7, 917-923 p.Article in journal (Refereed) Published
Abstract [en]

No large randomized multicentre trial has evaluated the efficacy of radiofrequency ablation (RFA) vs. anti-arrhythmic drug (AAD) therapy as a first-line treatment of paroxysmal atrial fibrillation (AF). The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation (MANTRA-PAF) trial is a randomized, controlled, parallel group, multicentre study designed to test whether catheter-based RFA is superior to optimized AAD therapy in suppressing relapse within 24 months of symptomatic and/or asymptomatic AF in patients with paroxysmal AF without prior AAD therapy. The primary endpoint is cumulative AF burden on repeated 7 days Holter monitoring. Secondary endpoints are: thromboembolic events, hospitalization due to arrhythmia, pro-arrhythmic events, procedure/treatment-related side effects, health economics, quality of life, and change in left ventricular function. Ten centres in Scandinavia and Germany are participating in the study. Enrolment was started in 2005 and as of November 2008, 260 patients have been enrolled into the study. It is expected that enrolment will end by March 2009, when 300 patients have been included. The MANTRA-PAF trial will determine whether catheter-based RFA is superior to optimized AAD therapy as a first-line treatment in suppressing long-term relapse of symptomatic and/or asymptomatic AF.

Place, publisher, year, edition, pages
2009. Vol. 11, no 7, 917-923 p.
Keyword [en]
Atrial fibrillation; Radiofrequency ablation; Anti-arrhythmic drugs; Randomized trial
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-20230DOI: 10.1093/europace/eup122OAI: oai:DiVA.org:liu-20230DiVA: diva2:234018
Available from: 2009-09-04 Created: 2009-08-31 Last updated: 2013-12-17

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Walfridsson, Håkan

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Cardiology Faculty of Health SciencesDepartment of Cardiology
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CiteExportLink to record
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