Rapid change of neuropeptide Y levels and gene-expression in the brain of ovariectomized mice after administration of 17 beta-estradiol
2009 (English)In: NEUROPEPTIDES, ISSN 0143-4179, Vol. 43, no 4, 327-332 p.Article in journal (Refereed) Published
Estrogen alters excitability and changes synaptic morphology in the rat hippocampal formation. We have compared, by means of radioimmunoassay and in situ hybridization, the effects of short-term treatment with 17 beta-estradiol on neuropeptide Y (NPY) in the brain of ovariectomized mice. A highly significant reduction in concentrations of NPY-like immunoreactivity (LI) was observed in the hippocampal formation, some cortical areas and the caudate nucleus 1 h after administration of 17 beta-estradiol as compared to the control group. In contrast, NPY transcript levels increased in the hippocampal formation (dentate gyrus) and the caudate nucleus, possibly representing a compensatory increase of NPY synthesis following increased estradiol-induced NPY release. These data suggest that 17 beta-estradiol, via membrane-related mechanisms, increases NPY release and synthesis in forebrain areas involved in cognition, mood and motor functions.
Place, publisher, year, edition, pages
2009. Vol. 43, no 4, 327-332 p.
Estrogen, In situ hybridization, Limbic system, Neuropeptide, Radioimmunoassay
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-20329DOI: 10.1016/j.npep.2009.04.005OAI: oai:DiVA.org:liu-20329DiVA: diva2:234028