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Cord blood cytokines and chemokines and development of allergic disease
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. (Landstinget i Östergötland)
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
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2009 (English)In: PEDIATRIC ALLERGY AND IMMUNOLOGY, ISSN 0905-6157, Vol. 20, no 6, 519-527 p.Article in journal (Refereed) Published
Abstract [en]

Exposure to ubiquitous allergens early in life, even before birth, may influence the incidence of allergic diseases later in life. During pregnancy, the fetomaternal interface is surrounded by high levels of T-helper (Th)2-like cytokines, possibly favouring the development of Th2-like immune responses in the offspring. The aim of this study was to evaluate the relation between cord blood (CB) IgE antibodies, Th1- and Th2-like cytokines and chemokines, maternal allergy and development of allergic disease during the first 2 yr of life in the offspring. The CB cytokine and chemokine levels from children of 20 allergic and 36 non-allergic women were determined by a multiplexed Luminex assay and ELISA. Total CB and maternal IgE antibody concentrations were quantified using ImmunoCAP technology. The maternal IgE levels during and after pregnancy correlated with CB IgE and Th2-associated macrophage-derived chemokine [MDC (CCL22)] levels. Development of allergic disease and sensitization was associated with increased CB IgE and MDC (CCL22) levels, as well as high ratios of MDC (CCL22) to Th1-associated interferon-gamma inducible protein 10 [IP-10 (CXCL10)] and interferon-gamma inducible T-cell alpha-chemoattractant [I-TAC (CXCL11) (n = 7 allergic vs. n = 25 non-allergic)]. The correlations between maternal IgE and CB IgE and MDC (CCL22) levels possibly indicate that the maternal immunity can affect the Th1/Th2 profile in the neonate. Development of allergic disease is associated with a more marked Th2-like deviation already at birth, shown as increased levels of CB IgE and MDC (CCL22) and higher ratios of MDC (CCL22) to IP-10 (CXCL10) and I-TAC (CXCL11).

Place, publisher, year, edition, pages
2009. Vol. 20, no 6, 519-527 p.
Keyword [en]
allergy, cytokines, chemokines, cord blood, IgE, luminex
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-20400DOI: 10.1111/j.1399-3038.2008.00794.xOAI: oai:DiVA.org:liu-20400DiVA: diva2:234510
Note

This is the pre-reviewed version of the following article: Martina Sandberg, Anne Frykman, Jan Ernerudh, Göran Berg, Leif Matthiesen, Christina Ekerfelt, Lennart Nilsson and Maria Jenmalm, Cord blood cytokines and chemokines and development of allergic disease, 2009, PEDIATRIC ALLERGY AND IMMUNOLOGY, (20), 6, 519-527. which has been published in final form at: http://dx.doi.org/10.1111/j.1399-3038.2008.00794.x Copyright: Blackwell Publishing Ltd http://www.blackwellpublishing.com/

Available from: 2009-09-09 Created: 2009-09-07 Last updated: 2013-11-07Bibliographically approved

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Sandberg, MartinaErnerudh, JanBerg, GöranMatthiesen, LeifEkerfelt, ChristinaNilsson, LennartJenmalm, Maria

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Sandberg, MartinaErnerudh, JanBerg, GöranMatthiesen, LeifEkerfelt, ChristinaNilsson, LennartJenmalm, Maria
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PediatricsFaculty of Health SciencesClinical ImmunologyDepartment of Clinical Immunology and Transfusion MedicineObstetrics and gynecologyDepartment of Gynaecology and Obstetrics in LinköpingAllergy Center
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