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Programmed cell death in the nervous system-a programmed cell fate?
University of Cambridge.
Linköping University, Department of Clinical and Experimental Medicine, Developmental Biology, IKE. Linköping University, Faculty of Health Sciences.
2009 (English)In: CURRENT OPINION IN NEUROBIOLOGY, ISSN 0959-4388, Vol. 19, no 2, 127-133 p.Article, review/survey (Refereed) Published
Abstract [en]

Studies of developmental cell death in the nervous system have revealed two different modes of programmed cell death (PCD). One results from competition for target-derived trophic factors and leads to the stochastic removal of neurons and/or glia. A second, hard-wired form of PCD involves the lineage-specific, stereotypical death of identifiable neurons, glia or undifferentiated cells. Although traditionally associated with invertebrates, this programmed PCD can also occur in vertebrates. Recent studies have shed light on its genetic control and have revealed that activation of the apoptotic machinery can be under the same complex, combinatorial control as the expression of terminal differentiation genes. This review will highlight these findings and will suggest why such complex control evolved.

Place, publisher, year, edition, pages
2009. Vol. 19, no 2, 127-133 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-20410DOI: 10.1016/j.conb.2009.04.002OAI: diva2:234521
Original Publication: Irene Miguel-Aliaga and Stefan Thor, Programmed cell death in the nervous system-a programmed cell fate? 2009, CURRENT OPINION IN NEUROBIOLOGY, (19), 2, 127-133. Copyright: Elsevier Science B.V., Amsterdam. Available from: 2009-09-09 Created: 2009-09-07 Last updated: 2010-05-24Bibliographically approved

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