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Heat shock proteins: keys to healthy ageing?
University of Sydney.
University of Sydney.
Linköping University, Department of Medicine and Health Sciences, Pharmacology . Linköping University, Faculty of Health Sciences.
2009 (English)In: REDOX REPORT, ISSN 1351-0002, Vol. 14, no 4, 147-153 p.Article, review/survey (Other academic) Published
Abstract [en]

Organisms produce reactive species throughout their lives, and this may result in damage to proteins and other biological molecules. Oxidatively damaged proteins are normally selectively degraded and replaced, but this process appears to be less efficient in senescent, long-lived post-mitotic cells, as is evidenced by their accumulation in the form of lipofuscin inside the lysosomal compartment. A great deal of research has focused on changes to the proteolytic machinery in the ageing cells in particular the proteasomes although failure of heat shock proteins (HSPs) to bind and deliver oxidised proteins efficiently to the degradation machinery could also contribute to their aggregation and accumulation. Oxidised proteins can be protease-resistant and may even directly inhibit the proteolytic machinery of the cellu The critical role that is played by HSPs in preventing accumulation of oxidised proteins is often overlooked. In this reviews we examine the key role played by HSPs in recognising, removing and preventing the formation of oxidised and damaged proteins in cells. We also examine the evidence supporting the view that failure of one of these pathways could underlie ageing and age-related diseases. Finally, we discuss how modulation of HSP-activity could influence the ageing process and the progression of age-related diseases.

Place, publisher, year, edition, pages
2009. Vol. 14, no 4, 147-153 p.
Keyword [en]
heat shock protein, oxidised protein, free radical, ageing, lipofuscin
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-20586DOI: 10.1179/135100009X392593OAI: diva2:235300
Available from: 2009-09-15 Created: 2009-09-15 Last updated: 2009-09-15

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Brunk, Ulf
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Pharmacology Faculty of Health Sciences
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