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Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland. (Landstinget i Östergötland)
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Oncology .
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Oncology .
Karolinska University Hospital.
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2009 (English)In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, ISSN 0360-3016, Vol. 75, no 1, 137-142 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: FXYD-3 (MAT-8) is overexpressed in several types of cancers; however, its clinical relevance in rectal cancers has not been studied. Therefore, we examined FXYD-3 expression in rectal cancers from the patients who participated in a Swedish clinical trial of preoperative radiotherapy (RT) to determine whether FXYD-3 was overexpressed in rectal cancers and correlated with RT, survival, and other clinicopathologic variables. Methods and Materials: The study included 140 rectal cancer patients who participated in a clinical trial of preoperative RT, 65 with and 75 without RT before surgery. FXYD-3 expression was immumohistochemically examined in distant (n = 70) and adjacent (n = 101) normal mucosa, primary tumors (n = 140), and lymph node metastasis (n = 36). Results: In the whole cohort, strong FXYD-3 expression was correlated with infiltrative tumor growth (p = 0.02). In the RT group, strong FXYD-3 expression alone (p = 0.02) or combined with phosphatase of regenerating liver was associated with an unfavorable prognosis (p = 0.02), independent of both TNM stage and tumor differentiation. In tumors with strong FXYD-3 expression, there was less tumor necrosis (p = 0.02) and a trend toward increased incidence of distant metastasis (p = 0.08) after RT. None of these effects was seen in the non-RT group. FXYD-3 expression in the primary tumors tended to he increased compared with normal mucosa regardless of RT. Conclusion: FXYD-3 expression was a prognostic factor independent of tumor stage and differentiation in patients receiving preoperative RT for rectal cancer.

Place, publisher, year, edition, pages
2009. Vol. 75, no 1, 137-142 p.
Keyword [en]
FXYD-3, Rectal cancer, Radiotherapy, Prognosis, Immunohistochemistry
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-20598DOI: 10.1016/j.ijrobp.2008.10.076OAI: diva2:235517
Available from: 2009-09-16 Created: 2009-09-15 Last updated: 2009-09-16

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Loftas, PerÖnnesjö, SofiaWidegren, EmmaSun, Xiao-Feng
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Department of Surgery in ÖstergötlandFaculty of Health SciencesOncology Department of Oncology UHL
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