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Clinical effects of purified air administered to the breathing zone in allergic asthma: A double-blind randomized cross-over trial
Karolinska University Hospital.
Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Allergy Centre UHL.
Karolinska University Hospital.
Karolinska University Hospital.
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2009 (English)In: RESPIRATORY MEDICINE, ISSN 0954-6111, Vol. 103, no 9, 1313-1319 p.Article in journal (Refereed) Published
Abstract [en]

Background: Exposure to inhaled allergens is a pathogenetic factor in allergic asthma. However, most studies that previously looked at air cleaning devices have shown little or no effect on patients with perennial allergic asthma. Aims and objectives: We examined a novel treatment using temperature regulated laminar airflow with a very low particle concentration directed to the breathing zone of teenagers and young adults with mild to moderate allergic asthma during night steep. We hypothesised that the decreased allergen exposure during the night would have an effect on bronchial inflammation and quality of life. Method: Twenty-two patients (mean 18.8 years) were randomized to start with active or placebo treatment for 10 weeks. At( patients received both active and placebo treatment with unfiltered air, with a 2-week wash-out period in between treatments. Maintenance treatment with inhaled corticosteroids was unaltered during the trial period. Health related quality of life (miniAQLQ) was the primary effectiveness measure. Exhaled nitric oxide (FeNO) and spirometry were also investigated. Results: Active treatment resulted in an improved miniAQLQ compared to placebo (mean score 0.54, p andlt; 0.05, n = 20). An effect on bronchial, inflammation was also detected with significantly tower FeNO values during the active treatment period (mean -6.95 ppb, p andlt; 0.05, n = 22). Both effects were evident after 5 weeks. The change in lung function was not statistically significant. Conclusion: Clean air, administered directly to the breathing zone during steep, can have a positive effect on bronchial. inflammation and quality of life in patients with perennial allergic asthma.

Place, publisher, year, edition, pages
2009. Vol. 103, no 9, 1313-1319 p.
Keyword [en]
Asthma, Controlled environment, Quality of life, Exhaled nitric oxide
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-20740DOI: 10.1016/j.rmed.2009.03.020OAI: diva2:235961
Available from: 2009-09-18 Created: 2009-09-18 Last updated: 2013-03-26

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Millinger, EvaZetterström, Olle
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