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Bone Resorption Induced by Fluid Flow
Linköping University, Department of Management and Engineering, Mechanics . Linköping University, The Institute of Technology.
Linköping University, Department of Management and Engineering, Mechanics . Linköping University, The Institute of Technology.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Linköping University, Faculty of Health Sciences.
2009 (English)In: Journal of Biomechanical Engineering, ISSN 0148-0731, E-ISSN 1528-8951, Vol. 131, no 9, 094505-1-094505-5 p.Article in journal (Refereed) Published
Abstract [en]

A model where bone resorption is driven by stimulus from fluid flow is developed and used as a basis for computer simulations, which are compared with experiments. Models for bone remodeling are usually based on the state of stress, strain, or energy density of the bone tissue as the stimulus for remodeling. We believe that there is experimental support for an additional pathway, where an increase in the amount of osteoclasts, and thus osteolysis, is caused by the time history of fluid flow velocity, fluid pressure, or other parameters related to fluid flow at the bone/soft tissue interface of the porosities in the bone.

Place, publisher, year, edition, pages
ASME , 2009. Vol. 131, no 9, 094505-1-094505-5 p.
Keyword [en]
bone resorption, constitutive model
National Category
Other Materials Engineering
Identifiers
URN: urn:nbn:se:liu:diva-20801DOI: 10.1115/1.3194756OAI: oai:DiVA.org:liu-20801DiVA: diva2:236088
Available from: 2009-09-21 Created: 2009-09-21 Last updated: 2017-12-13

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Johansson, LarsEdlund, UlfFahlgren, AnnaAspenberg, Per

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