Urinary 8-hydroxydeoxyguanosine in Belarussian children relates to urban living rather than radiation dose after the Chernobyl accident: A pilot study
2005 (English)In: Archives of Environmental Contamination and Toxicology, ISSN 0090-4341 (print) 1432-0703 (online), Vol. 48, no 4, 515-519 p.Article in journal (Refereed) Published
As a result of the Chernobyl accident in 1986, exposure to radioactive cesium is still a concern in the contaminated regions of Belarus. We tested the hypothesis that long-term radiation exposure from the Chernobyl accident might increase the urinary excretion of the oxidative stress marker, 8-hydroxydeoxyguanosine (8-OHdG), in Belarussian children. Urinary 8-OHdG was determined in two groups of children (—n = 31 and n = 46) —living in contaminated and uncontaminated areas of Belarus, respectively (the majority of the unexposed children lived in the capital Minsk). The children from the contaminated areas had a significantly higher annual summary effective dose but significantly lower urinary 8-OHdG levels than the children from the uncontaminated areas. Unexpectedly, children living in uncontaminated urban areas had significantly higher urinary 8-OHdG levels than children living in uncontaminated rural areas. There was no statistically significant effect of sex or body mass index on urinary 8-OHdG, but there was a weak significant inverse correlation to age as well as to the annual summary effective dose. These findings suggest that radiation from the Chernobyl accident is now a less important contributor to oxidative stress in Belarussian children than urban living.
Place, publisher, year, edition, pages
2005. Vol. 48, no 4, 515-519 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-14509DOI: 10.1007/s00244-004-0079-zOAI: oai:DiVA.org:liu-14509DiVA: diva2:23611