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De Novo Design and Characterization of Surface Binding Peptides - Steps toward Functional Surfaces
Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics . Linköping University, The Institute of Technology.
2006 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

The ability to create surfaces with well-defined chemical properties is a major research field. One possibility to do this is to design peptides that bind with a specific secondary structure to silica nanoparticles. The peptides discussed in this thesis are constructed to be random coil in solution, but are “forced” to become helical when adsorbed to the particles. The positively charged side-chains on the peptides strongly disfavor an ordered structure in solution due to electrostatic repulsion. When the peptides are introduced to the particles these charges will strongly favor the structure because of ion pair bonding between the peptide and the negatively charged nanoparticles. The peptide-nanoparticle system has been thoroughly investigated by systematic variations of the side-chains. In order to determine which factors that contributes to the induced structure, several peptides with different amino acid sequences have been synthesized. Factors that have been investigated include 1) the positive charge density, 2) distribution of positive charges, 3) negative charge density, 4) increasing hydrophobicity, 5) peptide length, and 6) by incorporating amino acids with different helix propensities. Moreover, pH dependence and the effect of different nanoparticle curvature have also been investigated. It will also be shown that the system can be modified to incorporate a catalytic site that is only active when the helix is formed. This research will increase our understanding of peptide-surface interactions and might be of importance for both nanotechnology and medicine.

Place, publisher, year, edition, pages
Institutionen för fysik, kemi och biologi , 2006. , 51 p.
Series
Linköping Studies in Science and Technology. Thesis, ISSN 0280-7971 ; 1254
Keyword [en]
Peptide, design, nanoparticle, CD, Amino acid
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-8992ISBN: 91-85523-57-7 (print)OAI: oai:DiVA.org:liu-8992DiVA: diva2:23693
Presentation
2006-06-16, Nobel, B-huset, Linköpings universitet, Linköping, 09:15 (English)
Opponent
Supervisors
Available from: 2008-02-25 Created: 2008-02-25 Last updated: 2009-03-09
List of papers
1. Induction of structure and function in a designed peptide upon adsorption on a silica nanoparticle
Open this publication in new window or tab >>Induction of structure and function in a designed peptide upon adsorption on a silica nanoparticle
2006 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 45, no 48, 8169-8173 p.Article in journal (Refereed) Published
Abstract [en]

No abstrack available.

Keyword
Amino acids, catalysis, helical structures, nanoparticles, peptides
National Category
Chemical Sciences
Identifiers
urn:nbn:se:liu:diva-14548 (URN)10.1002/anie.200600965 (DOI)
Available from: 2008-02-25 Created: 2008-02-25 Last updated: 2012-11-16Bibliographically approved
2. Optimizing Nanoparticle Induced Helical Structure in a De Novo Designed Peptide by Rational Changes in Amino Acid Sequence
Open this publication in new window or tab >>Optimizing Nanoparticle Induced Helical Structure in a De Novo Designed Peptide by Rational Changes in Amino Acid Sequence
Manuscript (Other academic)
Identifiers
urn:nbn:se:liu:diva-14549 (URN)
Available from: 2008-02-25 Created: 2008-02-25 Last updated: 2010-01-13

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Nygren, Patrik

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