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B vitamins improve health in patients with coeliac disease living on a gluten-free diet
Linköping University, Department of Social and Welfare Studies, Health, Activity, Care. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in the East of Östergötland, Department of Internal Medicine VHN.
Värnamo Hospital.
Eksjö Hospital .
Lund University Hospital.
2009 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 29, no 8, 811-816 p.Article in journal (Refereed) Published
Abstract [en]

Background Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status.

Aim To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease.

Methods In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45–64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status.

Results Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 μmol/L (7.4–23.0), significantly higher than in matched population controls [10.2 μmol/L (6.7–22.6) (P < 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P < 0.001), accompanied by significant improvement in well-being (P < 0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor well-being.

Conclusions Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet.

Place, publisher, year, edition, pages
2009. Vol. 29, no 8, 811-816 p.
Keyword [en]
Coeliac disease
National Category
Gastroenterology and Hepatology
URN: urn:nbn:se:liu:diva-20987DOI: 10.1111/j.1365-2036.2009.03945.xOAI: diva2:240272
Available from: 2009-09-27 Created: 2009-09-27 Last updated: 2010-10-01

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Hallert, Claes
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Health, Activity, CareFaculty of Health SciencesDepartment of Internal Medicine VHN
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