B vitamins improve health in patients with coeliac disease living on a gluten-free diet
2009 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 29, no 8, 811-816 p.Article in journal (Refereed) Published
Background Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status.
Aim To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease.
Methods In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45–64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status.
Results Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 μmol/L (7.4–23.0), significantly higher than in matched population controls [10.2 μmol/L (6.7–22.6) (P < 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P < 0.001), accompanied by significant improvement in well-being (P < 0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor well-being.
Conclusions Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet.
Place, publisher, year, edition, pages
2009. Vol. 29, no 8, 811-816 p.
Gastroenterology and Hepatology
IdentifiersURN: urn:nbn:se:liu:diva-20987DOI: 10.1111/j.1365-2036.2009.03945.xOAI: oai:DiVA.org:liu-20987DiVA: diva2:240272