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Engineering Design Methodology for Bio-Mechatronic Products
Linköping University, Department of Management and Engineering, Assembly technology . Linköping University, The Institute of Technology.
Linköping University, Department of Management and Engineering, Assembly technology . Linköping University, The Institute of Technology.
Linköping University, Department of Management and Engineering, Assembly technology . Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
2008 (English)In: Biotechnology progress (Print), ISSN 8756-7938, E-ISSN 1520-6033, Vol. 4, no 1, 232-244 p.Article in journal (Refereed) Published
Abstract [en]

Four complex biotechnology products/product systems (a protein purification system, a bioreactor system, a surface plasmon resonance biosensor, and an enzymatic glucose analyzer) are analyzed using conceptual design principles. A design model well-known in mechanical system design, the Hubka-Eder (HE) model, is adapted to biotechnology products that exemplify combined technical systems of mechanical, electronic, and biological components, here referred to as bio-mechatronic systems. The analysis concludes that an extension of the previous HE model with a separate biological systems entity significantly contributes to facilitating the functional and systematic analyses of bio-mechatronic systems.

Place, publisher, year, edition, pages
2008. Vol. 4, no 1, 232-244 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-21068DOI: 10.1021/bp0701822OAI: oai:DiVA.org:liu-21068DiVA: diva2:240505
Available from: 2009-09-28 Created: 2009-09-28 Last updated: 2017-12-13Bibliographically approved
In thesis
1. On Evaluation of Design Concepts: Modelling Approaches for Enhancing the Understanding of Design Solutions
Open this publication in new window or tab >>On Evaluation of Design Concepts: Modelling Approaches for Enhancing the Understanding of Design Solutions
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This dissertation embraces the issue of evaluating design concepts. Being able to sort out the potential“best solutions” from a set of solutions is a central and important part of the design process. The subjectdiscussed in this dissertation has its origins in the lack of knowledge about design concepts, somethingwhich is characteristic of the initial part of the design process and which frequently causes problems whenit comes to evaluation and selection of solutions. The purpose of this dissertation is to develop aids andmethods that enhance the understanding of design concepts in the early phases of the design process.

From deductive reasoning about the fundamental mechanisms of the evaluation activity, the work hasbeen divided into three different areas: process and system modelling, concept optimisation, andidentification of potential failures.

The bearing of the work within the area of process and system modelling has a verifying character. Theobjective of the work has been to analyse how established design methodology, which has its commonapplications within traditional engineering industry, may be applied within an area that is characterised bymore multidisciplinary interfaces, like biotechnology. The result of a number of case studies, in whichdifferent types of biotechnical systems where analysed and modelled, shows that the methodology isapplicable even for biotechnical products. During the work the methodology has also been furtherelaborated on in order to better suit the distinguishing characteristics exhibited in the development ofbiotechnical systems.

Within the area of concept optimisation, an approach for optimising the concept generation has beenelaborated. By formalising the step in both concept generation and evaluation, it has been possible toapply genetic algorithms in order to optimise the process. The work has resulted in a model thatautomatically creates and sorts out a number of potential solutions from a defined solution space and adefined set of goals.

The last area, which deals with identification of potential failures, has resulted in a rather novel way toconsider and model the behaviour of a system. The approach is an elaboration of the modellingtechniques within system theory, and deduces the system’s behaviour from known physical phenomenaand the system’s ability to effectuate them. The way the different behaviours interact with one another, byaffecting the properties of the system, determines the potential for a failure to occur. A “failure”,according to the model, is described as an unintended behaviour which obstructs the system’sfunctionality, i.e. which affects the conditions of a desired behaviour.

The dissertation has resulted in three different means for approaching the difficulties associated with theevaluation of design concepts. The means are applicable during different parts of the design process, butthey all address the same issue, viz. to enhance the understanding of the design solutions.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2009. 80 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1273
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-21085 (URN)978-91-7393-536-4 (ISBN)
Public defence
2009-10-23, C3, C-huset, Campus Valla, Linköpings universitet, Linköping, 13:15 (English)
Opponent
Supervisors
Available from: 2009-09-28 Created: 2009-09-28 Last updated: 2009-09-28Bibliographically approved

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Derelöv, MicaelDetterfelt, JonasBjörkman, MatsMandenius, Carl-Fredrik

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