liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome prolifertor-activated receptor-gamma activation
Franz Volhard Clinic.
Show others and affiliations
2006 (English)In: Journal of Hypertension, ISSN 0263-6352, Vol. 24, no 9, 1809-1816 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans. METHODS: We investigated the induction of in-vitro adipogenesis and the activation of PPARgamma-target genes, adiponectin and lipoprotein lipase, by ARB in human preadipocytes. We also studied PPARgamma response-element-driven luciferase reporter gene activation in human adipocytes. Finally, we treated 14 obese men for 10 days with placebo crossed over with 150 mg/day irbesartan. Subcutaneous fat was analyzed for mRNA expression of adiponectin and lipoprotein lipase. RESULTS: Telmisartan and irbesartan, and to a lesser degree losartan, induced adipogenesis and activated PPARgamma-target genes. This stimulation of PPARgamma-target genes was prevented by the PPARgamma antagonist GW9662. Eprosartan had no effect. Paradoxically, all ARB activated the luciferase reporter gene. PPARgamma activity increased approximately two-fold with pioglitazone and 1.5-fold with the ARB in all assays. In the cross-over clinical study, irbesartan lowered blood pressure but had no effect on adiponectin or lipoprotein lipase mRNA expression. CONCLUSIONS: Our data are the first to show that ARB induce adipogenesis and PPARgamma-target gene expression in human adipocytes. Pharmacokinetic differences may contribute to the heterogeneous effects on metabolism and preadipocyte differentiation. In humans, larger doses of ARB, longer treatments, or both may be required to activate PPARgamma in adipose cells.

Place, publisher, year, edition, pages
2006. Vol. 24, no 9, 1809-1816 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-21107DOI: 10.1097/01.hjh.0000242405.68461.84OAI: diva2:240613
Available from: 2009-09-29 Created: 2009-09-29 Last updated: 2013-09-10

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sauma, LilianNystrom, Fredrik H
By organisation
Internal MedicineFaculty of Health SciencesDepartment of Endocrinology and Gastroenterology UHLInternal Medicine
In the same journal
Journal of Hypertension
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link